期刊
MARINE DRUGS
卷 21, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md21010022
关键词
Lumnitzera littorea; Penicillium oxalicum; secondary metabolites; biological activity
Five new compounds were isolated from the fermentation broth of Penicillium oxalicum HLLG-13, a fungus derived from Lumnitzera littorea. These compounds, along with ten known compounds, were identified through spectral analyses. Some of the compounds exhibited antibacterial and insecticidal activities.
Five new compounds, including two cyclopiane diterpenes conidiogenones J and K (1-2), a steroid andrastin H (5), an alkaloid (Z)-4-(5-acetoxy-N-hydroxy-3-methylpent-2-enamido) butanoate (6), and an aliphatic acid (Z)-5-acetoxy-3-methylpent-2-enoic acid (7), together with ten known compounds (3-4 and 8-15) were isolated from the EtOAc extract of the fermentation broth of the Lumnitzera littorea-derived fungus Penicillium oxalicum HLLG-13. Their structures were elucidated by 1D, 2D NMR, and HR-ESI-MS spectral analyses. The absolute configurations of 1, 2, 5, and 8 were determined by quantum chemical electronic circular dichroism (ECD) calculations, and the absolute configuration of 8 was determined for the first time. Compound 15 was a new natural product, and its NMR data were reported for the first time. Compounds 5 and 9-14 exhibited antibacterial activities against Staphylococcus epidermidis and Candida albicans, with MIC values ranging from 6.25 to 25 mu g/ mL. Compounds 1-6 and 9-14 showed significant growth inhibition activities against newly hatched Helicoverpa armigera Hubner larvae, with IC50 values ranging from 50 to 200 mu g/mL.
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