期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 105, 期 9, 页码 2621-2624出版社
WILEY-BLACKWELL
DOI: 10.1016/j.xphs.2016.02.017
关键词
solubility; polymers; poorly soluble drugs; Flory-Huggins; shake-flask method; amorphous solid dispersion; solubility enhancement; thermal analysis
The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically. (c) 2016 American Pharmacists Association((R)). Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据