期刊
MACROMOLECULES
卷 56, 期 3, 页码 815-823出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.2c01944
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Petroleum-based polyolefin plastics have unsustainable life cycles, but they can be transformed into water-soluble antimicrobial polymers to combat the spread of fungal pathogens. This study demonstrates the conversion of polyethylene into low-molecular-weight antimicrobial polymers with potential applications in controlling fungal infections.
Petroleum-based polyolefin plastics currently pos-sess highly unsustainable cradle-to-grave linear life cycles. Using them as a resource for the production of new functional polymers not only decreases the generated waste but also reduces our reliance on petroleum-derived monomers for traditional bottom-up synthesis of new polymeric materials. Herein, we demonstrate that polyethylene (PE), the most abundant plastic in production today, can be transformed into low-molecular-weight water-soluble antimicrobial polymers. In this proof-of-concept study, organocatalytic C-H aerobic oxidation of PE was first achieved to append reactive oxygenated and chloro functional groups onto the inert polymer chains, followed by further chemical modifications to form water-soluble amphiphilic polymers. Our first-generation polymer showed antimicrobial efficacy against opportunistic pathogenic Candida fungi without appreciable hemolysis even at high concentrations (2 mg/mL). The PE-derived antimicrobial polymer may find applications to combat the spread of fungal pathogens.
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