Controlling Radical Polymerization with Biocatalysts

Reversible deactivation radical polymerization (RDRP) is a set of powerful and versatile methods for the synthesis of well-defined polymers. Over the past two decades, the engagement of biocatalysts, namely, enzymes and bacteria, has granted distinctive features to RDRP and propelled RDRP toward a more sustainable future. In this Perspective, we highlight the green conditions, oxygen tolerance, versatile function, and the ability to access difficult polymers in RDRP conducted by biocatalysis (bioRDRP), discuss major considerations when conducting bio-RDRP, and point out the drawbacks and bottlenecks that limit its further development. The future of bio-RDRP may benefit from expanding the biocatalyst library, improving the redox potential of bacteria, enhancing the biocatalyst robustness, and in-depth mechanistic studies.

Automated summary

Reversible deactivation radical polymerization (RDRP) is a powerful method for synthesizing well-defined polymers, and the involvement of biocatalysts has enhanced its sustainability. In this Perspective, the green conditions, oxygen tolerance, versatile function, and access to difficult polymers in bioRDRP are highlighted. The future of bioRDRP may benefit from expanding the biocatalyst library, improving bacterial redox potential, enhancing biocatalyst robustness, and conducting mechanistic studies.