期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 105, 期 2, 页码 406-416出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2015.10.018
关键词
carbon monoxide; CO-RMs; targeted delivery; metal free; photosensitive; enzyme activated
资金
- National Institutes of Health [CA180519, AI104168, CA180805]
Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the therapeutic potential of carbon monoxide. However, such studies were mostly based on CO inhalation and metal-based CO-releasing molecules. The field is now at the stage that a major effort is needed to develop pharmaceutically acceptable forms of CO for delivery via various routes such as oral, injection, infusion, or topical applications. This review examines the state of the art, discusses the existing hurdles to overcome, and proposes developmental strategies necessary to address remaining drug delivery issues. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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