期刊
MACROMOLECULAR BIOSCIENCE
卷 23, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202200349
关键词
adhesive hydrogel; antibacterial hydrogel; conductive hydrogel; tissue-liked hydrogel; wound healing hydrogel
This study developed a hydrogel with tissue adhesivity, conductivity, and antibacterial function, which showed promising results in promoting diabetic wound healing.
Diabetic mellitus is one of the leading causes of chronic wounds and remains a challenging issue to be resolved. Herein, a hydrogel with conformal tissue adhesivity, skin-like conductivity, robust mechanical characteristics, as well as active antibacterial function is developed. In this hydrogel, silver nanoparticles decorated polypyrrole nanotubes (AgPPy) and cobalt ions (Co2+) are introduced into an in situ polymerized poly(acrylic acid) (PAA) and branched poly(ethylenimine) (PEI) network (PPCA hydrogel). The PPCA hydrogel provides active antibacterial function through synergic effects from protonated PEI and AgPPy nanotubes, with a tissue-like mechanical property (approximate to 16.8 +/- 4.5 kPa) and skin-like electrical conductivity (approximate to 0.048 S m(-1)). The tensile and shear adhesive strength (approximate to 15.88 and approximate to 12.76 kPa, respectively) of the PPCA hydrogel is about two- to threefold better than that of fibrin glue. In vitro studies show the PPCA hydrogel is highly effective against both gram-positive and gram-negative bacteria. In vivo results demonstrate that the PPCA hydrogel promotes diabetic wounds with accelerated healing, with notable inflammatory reduction and prominent angiogenesis regeneration. These results suggest the PPCA hydrogel provide a promising approach to promote diabetic wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据