Hepatitis B virus receptor: Structure and therapeutic implications

Article Multidisciplinary Sciences

Structural insights into the HBV receptor and bile acid transporter NTCP

Jae-Hyun Park et al.

Summary: Around 250 million people worldwide are infected with hepatitis B virus (HBV), and 15 million of them may also carry hepatitis D virus (HDV), which increases the risk of severe liver disease. The structure of the HBV receptor NTCP has not been solved, but using cryo-electron microscopy, the structure of NTCP bound to an antibody has been determined. Comparison with other related proteins reveals a common mechanism of bile acid transport, and the NTCP structure presents a new pocket for potential drug design.

NATURE (2022)

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Article Multidisciplinary Sciences

Structural basis of sodium-dependent bile salt uptake into the liver

Kapil Goutam et al.

Summary: This study provides molecular insights into the key conformations of NTCP transport cycle and the recognition mechanisms of HBV/HDV receptors. These findings are expected to contribute to the development of liver disease therapies targeting NTCP.

NATURE (2022)

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Article Multidisciplinary Sciences

Structure of the bile acid transporter and HBV receptor NTCP

Jinta Asami et al.

Summary: Chronic infection with hepatitis B virus (HBV) requires interaction between the large glycoproteins of the virus envelope (LHBs) and the host entry receptor sodium taurocholate co-transporting polypeptide (NTCP). This study reveals the structures of NTCP and identifies a possible transport route for substrate. Furthermore, the study suggests a binding mode between LHBs and NTCP, which explains naturally occurring HBV-insusceptible mutations in NTCP.

NATURE (2022)

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Article Biochemical Research Methods

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Tomasz Uchanski et al.

Summary: Nanobodies are versatile tools for structural biology that can help overcome obstacles in single-particle cryo-electron microscopy reconstructions. Engineered megabodies, which have increased molecular weight while retaining specificity and affinity, are applicable to different scaffold proteins and recognition domains, and are useful for obtaining three-dimensional reconstructions for membrane proteins with severe preferential orientation.

NATURE METHODS (2021)

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Article Medicine, Research & Experimental

Cryo-electron microcopy for a new vision of the cell and its components

Daniel Levy et al.

Summary: Cryo-electron microscopy is a technique for imaging biological samples that plays a central role in structural biology. It has high impact on various research fields and allows for the determination of structures of purified proteins within cells. Future development includes further advancing the technology and expanding its applications.

M S-MEDECINE SCIENCES (2021)

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Article Pharmacology & Pharmacy