4.5 Article

Three-year results of renal function in liver transplant recipients on low-dose sirolimus and tacrolimus: a multicenter, randomized, controlled trial

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Summary: This study analyzed the effectiveness of an everolimus-based quadruple low calcineurin inhibitor (CNI) regimen compared to a standard triple regimen in patients who underwent lung transplantation. The results showed that there was no significant difference in renal function between the two regimens, but the quadruple low CNI regimen had a higher incidence of thromboembolic events. There was a trend towards higher survival rates for chronic lung allograft dysfunction in the quadruple low CNI regimen. Overall, the everolimus-based quadruple low CNI regimen appeared to be comparable to the standard triple regimen in terms of immunosuppressive efficacy and safety.

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