期刊
CELL
卷 162, 期 3, 页码 467-469出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.07.030
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资金
- NIAID NIH HHS [R01 AI107759] Funding Source: Medline
- NIDDK NIH HHS [F30 DK105680, R01 DK093015, R01 DK103744, P01 DK071176] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008361, T32GM008361] Funding Source: Medline
Mendelian genetics presumes inheritance of fitness through DNA. Kinder et al. find that maternal microchimerism induces stable immune tolerance to non-inherited maternal antigens in offspring. Female offspring that share these antigens with their mate experience reduced fetal wasting, establishing a role for vertical transmission of non-genetic information in reproductive fitness.
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