4.7 Article

Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases

B. Tedesco et al.

Summary: The family of HSPBs plays a crucial role in maintaining proteostasis and cellular homeostasis in response to stress and apoptosis. They prevent protein aggregation, promote refolding, and can be associated with various diseases when mutations occur. High expression levels of HSPBs are found in cardiac muscle, skeletal muscle, and neurons, and mutations in specific HSPBs can lead to cardiomyopathies, myopathies, and cataract.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Biochemistry & Molecular Biology

Autophagy Dysfunction in ALS: from Transport to Protein Degradation

Marta Cozzi et al.

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by mutations in more than 40 genes. Dysfunctions in autophagy play a central role in the progression of the disease.

JOURNAL OF MOLECULAR NEUROSCIENCE (2022)

Review Biochemistry & Molecular Biology

The role of autophagy-lysosomal pathway in motor neuron diseases

Barbara Tedesco et al.

Summary: Motor Neuron Diseases (MNDs) encompass a broad range of diseases characterized by neurodegeneration mainly affecting upper and/or lower motor neurons (MNs). The common pathogenic mechanism of most MNDs is alteration in proteostasis and proteotoxicity. This mechanism is often associated with gene mutations involved in the protein quality control system, particularly the autophagy-lysosomal pathway (ALP). Moreover, proteostasis alteration can also be caused by misfolded and aggregated proteins that cannot be properly handled by the ALP. This review discusses the features of the ALP, its relation to intracellular trafficking, mutated genes associated with MNDs, and the therapeutic potential of autophagy modulation in treating MNDs.

BIOCHEMICAL SOCIETY TRANSACTIONS (2022)

Article Biochemistry & Molecular Biology

Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model

Ganesh Routholla et al.

Summary: The HDAC3 selective inhibitor 11a demonstrates promising anticancer activity in vitro with low toxicity towards normal cells, showing potential application in tumors like breast cancer.

BIOORGANIC CHEMISTRY (2021)

Review Neurosciences

C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside

Sivakami Mylvaganam et al.

Summary: Neurodegenerative diseases are characterized by the dysfunction and death of neurons, leading to impairments in mobility and cognition. Protein misfolding and aggregation are hypothesized to be the cause of neurotoxicity in these diseases. CHIP may have therapeutic potential for the treatment of multiple neurodegenerative diseases.

CURRENT NEUROPHARMACOLOGY (2021)

Review Cell Biology

The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer

Riccardo Cristofani et al.

Summary: HSPB8, as a protein, plays a crucial role in cancer-induced stress response. It participates in selective autophagy, cell division, inflammation regulation, and has dual roles in tumors, affecting the acquisition of chemoresistance.
Article Cell Biology

CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies

Carole Luthold et al.

Summary: The cochaperone BAG3, in complex with HSPB8, plays a crucial role in mitotic cell shape remodeling and ensures the fidelity of cell shape by regulating the assembly of p62/SQSTM1 molecules and K63 polyubiquitinated chains.
Review Biochemistry & Molecular Biology

Ubiquitin-proteasome system and the role of its inhibitors in cancer therapy

Fatemeh Aliabadi et al.

Summary: Despite the potential of other cells to prevent cancer development, cancer cells can upregulate the ubiquitin-proteasome system (UPS) to degrade tumour suppressor proteins and avoid apoptosis. Understanding UPS inhibitors is crucial in controlling cancer development, with the need to improve inhibitors for more effective cancer therapy.

OPEN BIOLOGY (2021)

Article Chemistry, Medicinal

Dissecting Histone Deacetylase 3 in Multiple Disease Conditions: Selective Inhibition as a Promising Therapeutic Strategy

Nilanjan Adhikari et al.

Summary: Acetylation of histone and non-histone proteins has been linked to various disease states, making histone deacetylase 3 (HDAC3) an important drug target. Despite efforts, few selective inhibitors for HDAC3 have been reported, with research discussing its role in different diseases and various potential inhibitors. This could lead to the discovery of newer, more effective, and selective HDAC3 inhibitors.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7

Margherita Piccolella et al.

Summary: This study investigated the impact of retinoic acid (RA) on the gene expression of small heat shock protein B8 (HSPB8) and BCL-2 associated athanogene 3 (BAG3) in breast cancer cells. The results showed that RA can decrease the expression of both HSPB8 and BAG3 genes, and also affect the mitotic spindle organization in the cells. The effects of RA on HSPB8 levels are suggested to be mediated by miR-574-5p, highlighting a potential therapeutic strategy for counteracting HSPB8 in breast cancer progression.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

The eIF2 alpha kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Tapas Mukherjee et al.

Summary: HRI controls autophagy to clear cytosolic protein aggregates, particularly when the ubiquitin-proteasome system is inhibited. It may regulate cytosolic proteostasis in part through chaperone-assisted selective autophagy, and knocking down HRI expression results in cytotoxic accumulation of proteins like alpha-synuclein.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

Jack M. Webster et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Geriatrics & Gerontology

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

Riccardo Cristofani et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Review Cell Biology

Small heat shock proteins: multifaceted proteins with important implications for life

Serena Carra et al.

CELL STRESS & CHAPERONES (2019)

Article Medicine, General & Internal

Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis

Matteo Bordoni et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Chemistry, Medicinal

Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides

Alberto Bresciani et al.

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Article Cell Biology

Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells

Riccardo Cristofani et al.

CELL DEATH & DISEASE (2018)

Article Cell Biology

The growing world of small heat shock proteins: from structure to functions

Serena Carra et al.

CELL STRESS & CHAPERONES (2017)

Article Biochemistry & Molecular Biology

The Role of the Protein Quality Control System in SBMA

Paola Rusmini et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2016)

Review Pharmacology & Pharmacy

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

Christian Behl

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Multidisciplinary Sciences

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

D. R. Whiten et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

Enrico Luchinat et al.

NATURE COMMUNICATIONS (2014)

Article Geriatrics & Gerontology

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy

Paola Rusmini et al.

NEUROBIOLOGY OF AGING (2013)

Review Biology

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders

Serena Carra et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2013)

Article Chemistry, Multidisciplinary

Open-source platform to benchmark fingerprints for ligand-based virtual screening

Sereina Riniker et al.

JOURNAL OF CHEMINFORMATICS (2013)

Article Clinical Neurology

BAG3 mutations: another cause of giant axonal neuropathy

Fatima Jaffer et al.

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2012)

Article Clinical Neurology

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Faisal Fecto et al.

ARCHIVES OF NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

Martin Gamerdinger et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis

Elisa Onesto et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Inhibition of α-synuclein aggregation by small heat shock proteins

Ilona B. Bruinsma et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)

Article Biochemistry & Molecular Biology

Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction

Margit Fuchs et al.

BIOCHEMICAL JOURNAL (2010)

Article Biochemistry & Molecular Biology

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

Verena Arndt et al.

CURRENT BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Small Heat Shock Proteins and Protein-Misfolding Diseases

Ewa Laskowska et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

Article Clinical Neurology

Mutation in BAG3 Causes Severe Dominant Childhood Muscular Dystrophy

Duygu Selcen et al.

ANNALS OF NEUROLOGY (2009)

Article Biochemistry & Molecular Biology

HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation

Serena Carra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy

Serena Carra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Mutation of SOD1 in ALS: a gain of a loss of function

Daniela Sau et al.

HUMAN MOLECULAR GENETICS (2007)

Article Biochemistry & Molecular Biology

Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines

HA Braun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Genetics & Heredity

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

J Irobi et al.

NATURE GENETICS (2004)

Article Multidisciplinary Sciences

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

M Hafezparast et al.

SCIENCE (2003)

Article Clinical Neurology

Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations

D Selcen et al.

ANNALS OF NEUROLOGY (2003)

Article Cell Biology

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

JA Johnston et al.

CELL MOTILITY AND THE CYTOSKELETON (2002)

Article Multidisciplinary Sciences

Impairment of the ubiquitin-proteasome system by protein aggregation

NF Bence et al.

SCIENCE (2001)

Review Cell Biology

Aggresomes, inclusion bodies and protein aggregation

RR Kopito

TRENDS IN CELL BIOLOGY (2000)

Article Cell Biology

Conformational disease

RR Kopito et al.

NATURE CELL BIOLOGY (2000)