期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 130, 期 -, 页码 81-99出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2016.04.024
关键词
Capillary electrochromatography; Enantioseparation; Pharmaceuticals
The chiral separation of pharmaceuticals is one of the major research topics in the pharmaceutical industry. Chromatographic techniques are most frequently used in this context. Separations in capillary electrochromatography (CEC) are an alternative and achieved by chromatographic retention and electrophoretic mobility principles. As a result, CEC is characterized by a high selectivity and efficiency. The limited number of stationary phases specifically developed for CEC, the low number of commercially available CEC columns, the fits to maintain the stationary phase, which forms fragile spots in the columns, and the limited column robustness and reproducibility, make CEC not very attractive for industrial application. However, CEC is still applied and studied in the academic field. This review discusses the enantioseparation of drugs in CEC published during the last four years, with a critical view on the reproducibility and the practical utility of these applications. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据