期刊
KIDNEY INTERNATIONAL
卷 102, 期 6, 页码 1212-1214出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2022.09.004
关键词
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资金
- National Natural Science Foundation of China for Excellent Young Scholars [82222013]
- Hunan Natural Science Foundation for Distinguished Young Scholars [2021JJ10075]
- Veterans Affairs Merit Award [IBX000345C]
- National Institutes of Health (NIH) [1R01DK078897]
- NIH [R01DK117913, 1R01DK088541, P01DK56492]
Disulfiram, an inhibitor of FROUNT, attenuates crescentic GN by inhibiting the FROUNT-CCR2 interaction and macrophage migration and activation.
Macrophage accumulation in the kidney is associated with the progression of crescentic glomerulonephritis ( GN) and is mostly derived from circulating monocytes. FROUNT, a C-C motif chemokine receptor 2 (CCR2)-interacted protein, which is strongly expressed in monocytes/macrophages, enhances macrophage infiltration through CCR2-mediated chemotaxis. In this issue of the journal, Toda et al. reported that disulfiram, an inhibitor of FROUNT, attenuates GN by inhibition of the FROUNT-CCR2 interaction and macrophage migration and activation, suggesting a potential therapeutic role for crescentic GN.
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