Study on swelling, compression property and degradation stability of PVA composite hydrogels for artificial nucleus pulposus

Artificial nucleus pulposus (ANP) replacement as an alternative to the treatment of cervical spondylosis aims to relieve pain and restore the normal cervical motion. In this study, the PVA/PVP and PVA/Pectin composite hydrogels (CH)s with different concentrations were prepared by the freezing-thawing process, and their performances were tested. The effect of different concentrations on both kinds of PVA CHs were evaluated and analysed. The results demonstrated that both kinds of CHs had good swelling property (>190%), compressive stress-strain characteristic response and stable performance, and they were not easy to degrade (<9%). The elastic modulus of the PVA/PVP CH was close to that of nucleus pulposus prosthesis, and the weight loss ratio of the PVA/PVP CH was lower than that of PVA/Pectin CH under load condition. Further, the experimental results showed that the PVA/PVP CH with 15 wt% solute and 1 wt% PVP content had the best comprehensive performance, which may provide significant advantages for use in future clinical application in replacing nucleus pulposus.

Automated summary

In this study, PVA/PVP and PVA/Pectin composite hydrogels were prepared and tested, with the PVA/PVP CH showing the best performance, providing significant advantages for future clinical application in replacing nucleus pulposus.