期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 137, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2022.105552
关键词
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Cartilage defects are common and can lead to osteoarthritis. Hydrogels are a promising strategy for regenerating tissue, but commonly used hydrogels are too soft for joint load-bearing. To address this, an implant is being developed that uses osmotic pressure generated by a charged hydrogel and restricted swelling to provide mechanical load-bearing function. This study aims to quantify the relationship between hydrogel swelling potential and implant compressive stiffness.
Cartilage defects occur frequently and can lead to osteoarthritis. Hydrogels are a promising regenerative strategy for treating such defects, using their ability of mimicking the native extracellular matrix. However, commonly used hydrogels for tissue regeneration are too soft to resist load-bearing in the joint. To overcome this, an implant is being developed in which the mechanical loadbearing function originates from the osmotic pressure generated by the swelling potential of a charged hydrogel, which is restricted from swelling by a textile spacer fabric. This study aims to quantify the relationship between the swelling potential of the hydrogel and the compressive stiffness of the implant.
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