Correlation of adverse effects and antibody responses following homologous and heterologous COVID19 prime-boost vaccinations

Article Immunology

Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff

Yoshifumi Uwamino et al.

Summary: This study investigated the impact of sex, age, and adverse reactions on antibody response to the BNT162b2 vaccine among Japanese participants. The results showed that female, young, and participants with adverse reactions had higher antibody titers after vaccination.

VACCINE (2022)

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Article Immunology

Adverse Effects and Antibody Titers in Response to the BNT162b2 mRNA COVID-19 Vaccine in a Prospective Study of Healthcare Workers

Si'Ana A. Coggins et al.

Summary: The severity of postvaccination symptoms does not correlate with the magnitude of vaccine-induced antibody levels one month after receiving the Pfizer/BioNTech BNT162b2 vaccine. Additional findings include an inverse correlation between symptoms and age/weight, along with more frequent systemic symptoms after the second vaccination and lower antibody titers in older individuals.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Pathology

Antibody response and self-reported adverse reactions following vaccination with Comirnaty: a pilot study from a Croatian university hospital

Ivana Lapic et al.

Summary: This study found that there was an average 100-fold increase in antibody titres in naive vaccinees between the two time points, and participants aged below 50 had higher antibody titres. All reported adverse reactions were mild-to-moderate, with more participants declaring systemic reactions after the second dose.

JOURNAL OF CLINICAL PATHOLOGY (2022)

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Article Medicine, General & Internal

Original Article Immune response and safety of heterologous ChAdOx1-nCoV-19/mRNA-1273 vaccination compared with homologous ChAdOx1-nCoV-19 or homologous mRNA-1273 vaccination

Wang-Huei Sheng et al.

Summary: This study investigated the efficacy and safety of heterologous prime-boost vaccination with ChAdOx1 and mRNA-1273 vaccines. The results showed that the heterologous vaccination provided higher immunogenicity compared to the homologous ChAdOx1 vaccination, and it was comparable to the homologous mRNA-1273 vaccination. Most adverse events were mild and transient. Heterologous boosting at 8 weeks resulted in fewer adverse events.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

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Article Immunology

Systemic Adverse Effects Induced by the BNT162b2 Vaccine Are Associated with Higher Antibody Titers from 3 to 6 Months after Vaccination

Ryousuke Koike et al.

Summary: This study investigated the relationship between vaccine-related adverse effects and antibody titers from 3 to 6 months after the second dose of the BNT162b2 vaccine. The results showed that participants with systemic adverse effects had higher antibody titers during this period. Therefore, our findings may encourage vaccination, even among individuals with vaccine hesitancy due to relatively common systemic adverse effects.

VACCINES (2022)

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Article Immunology

Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2

Stilla Bauernfeind et al.

Summary: This study found that severe adverse reactions after vaccination with the BNT162b2 vaccine can significantly impact humoral immune response in men, but not in women or T-cell-mediated immune response.

VACCINES (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Article Immunology

Evidence for antibody as a protective correlate for COVID-19 vaccines

Kristen A. Earle et al.

Summary: The study found a strong correlation between antibody titers and efficacy when assessing different COVID-19 vaccines, supporting the use of post-immunization antibody titers as the basis for establishing a correlate of protection for COVID-19 vaccines.

VACCINE (2021)

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Review Immunology

The how's and what's of vaccine reactogenicity

Caroline Herve et al.

NPJ VACCINES (2019)

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Correlation of adverse effects and antibody responses following homologous and heterologous COVID19 prime-boost vaccinations

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