Excessive Dietary Salt Intake Exacerbates Cognitive Impairment Progression and Increases Dementia Risk in Older Adults

Article Clinical Neurology

Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia

Thomas J. Littlejohns et al.

Summary: Hypertension was associated with an increased risk of dementia regardless of genetic risk for dementia. The risk difference between those with and without hypertension was larger among those at higher genetic risk.

ALZHEIMERS & DEMENTIA (2023)

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Article Clinical Neurology

Dementia Incidence, APOE Genotype, and Risk Factors for Cognitive Decline in Aboriginal Australians A Longitudinal Cohort Study

Louise M. Lavrencic et al.

Summary: This study found a higher incidence of dementia in urban Aboriginal Australians and identified factors such as age, gender, work history, polypharmacy, past smoking, and the presence of APOE epsilon 4 allele associated with incident MCI/dementia in this population.

NEUROLOGY (2022)

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Article Medicine, General & Internal

Association of Systolic Blood Pressure With Dementia Risk and the Role of Age, U-Shaped Associations, and Mortality

Jan Willem van Dalen et al.

Summary: The study found that higher systolic blood pressure levels were associated with lower dementia risk in older individuals, and more distinctly U-shaped associations appeared for those over 75 years old. These findings may warrant future trials on tailored blood pressure management in older age groups, taking life expectancy and health context into consideration.

JAMA INTERNAL MEDICINE (2022)

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Article Geriatrics & Gerontology

Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life

Hao Ma et al.

Summary: The study examined the interaction between educational attainment and genetic susceptibility on dementia risk among adults over 60 years old. It found that low education attainment was significantly associated with higher dementia risk in individuals carrying the APOE epsilon 4 alleles. The combination of low educational attainment and high APOE epsilon 4-related genetic risk increased the risk of dementia more than the individual effects of each factor.

GEROSCIENCE (2022)

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Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

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Article Cardiac & Cardiovascular Systems