期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 80, 期 24, 页码 2314-2330出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2022.09.046
关键词
atrial fibrillation; atrial functional mitral regurgitation; atrial functional tricuspid regurgitation; atriogenic leaflet tethering; hamstringing; mitral annulus
The conventional view suggests that functional mitral regurgitation (MR) is caused by displacement of the papillary muscle-bearing segments of the left ventricle, but recent evidence shows that left atrial enlargement can also be a cause of functional MR.
The conventional view holds that functional mitral regurgitation (MR) is caused by restriction of leaflet motion resulting from displacement of the papillary muscle-bearing segments of the left ventricle. In the past decade, evidence has accrued suggesting functional MR can also be caused by left atrial enlargement. This underrecognized cause of secondary MR-atrial functional MR (AF-MR)-is mechanistically linked to annular enlargement, perturbations of annular contraction, and atriogenic leaflet tethering. AF-MR has been described in patients with atrial fibrillation and heart failure with preserved ejection fraction. Preliminary data suggest rhythm control may decrease MR severity in patients with atrial fibrillation. Additionally, several studies have reported reductions in MR and symptomatic improvement with restrictive annuloplasty and transcatheter edge-to-edge repair. This review discusses the pathophysiology, echocardiographic diagnosis, and treatment of AF-MR. AF-tricuspid regurgitation is also discussed. (c) 2022 by the American College of Cardiology Foundation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据