期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 144, 期 50, 页码 23001-23009出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c10021
关键词
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资金
- NSFC [21772208, 22271296]
- Natural Science Foundation of Jiangsu Province [BK20201193]
- Major Program of the Lanzhou Institute of Chemical Physics [ZYFZFX-1]
A new regio- and stereoselective reductive coupling of alkynes and crotononitrile has been developed using visible light organophotoredox cobalt dual catalysis, resulting in the synthesis of enantioenriched homoallylic nitriles with stereodefined trisubstituted alkene.
A new regio-and stereoselective reductive coupling of alkynes and crotononitrile has been developed via visible light organophotoredox cobalt dual catalysis. A variety of enantioenriched homoallylic nitriles bearing a stereodefined trisubstituted alkene have been easily synthesized with good to excellent regio-(up to >20:1 rr), stereo-(>20:1 E/Z), and enantioselectivity (up to 98% ee) control under mild conditions. The corresponding nitrile products were smoothly converted into various chiral building blocks. Remarkably, a simple organic base together with water have been utilized as hydrogen sources in this photoinduced reductive reaction.
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