A novel superparamagnetic iron oxide nanoparticles-based SPECT/MRI dual-modality probe for tumor imaging

Multimodal imaging has become a trend in the development of molecular imaging. For SPECT/MRI dual-modality imaging, we developed a SPECT/MRI dual-modality probe based on superparamagnetic iron oxide nanoparticles. RGDyk peptide and DTPA chelator were used to realize the functionalization of nanoparticles. Both SPECT imaging and T2-weighted MR imaging in vivo on 4T1 tumor-bearing mice showed targeting of the probe, demonstrating the potential of the SPECT/MRI dual-modality probe as a tool for tumor evaluation and diagnosis.

Automated summary

Multimodal imaging is a growing trend in molecular imaging. In this study, a SPECT/MRI dual-modality probe was developed using superparamagnetic iron oxide nanoparticles. The nanoparticles were functionalized using RGDyk peptide and DTPA chelator. In vivo SPECT imaging and T2-weighted MR imaging on tumor-bearing mice demonstrated the targeting of the probe, indicating the potential of the SPECT/MRI dual-modality probe for tumor evaluation and diagnosis.