期刊
JOURNAL OF PERINATAL MEDICINE
卷 44, 期 3, 页码 261-268出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpm-2014-0346
关键词
Birth defects; folic acid; fortification; pregnancy; serum folate
资金
- Working Group Spina bifida/Hydrocephalus (Arbeitsgemeinschaft Spina bifida/ Hydrozephalus
- ASBH)
- Professional Association of Gynecologists and Obstetricians (Berufsverband der Frauenarzte
- BVF)
- Professional Association of Paediatricians (Berufsverband der Kinder- und Jugendarzte
- BVKJ)
- German Society for Nutritional Medicine (Deutsche Gesellschaft fur Ernahrungsmedizin
- DGEM)
- German Society of Gynecology and Obstetrics (Deutsche Gesellschaft fur Gynakologie und Geburtshilfe
- DGGG)
- German Society of Human Genetics (Deutsche Gesellschaft fur Humangenetik
- GfH)
- German Society for Internal Medicine (Deutsche Gesellschaft fur Innere Medizin
- DGIM)
- German Society for Children and Youth Medicine (Deutsche Gesellschaft fur Kinder- und Jugendmedizin
- DGKJ)
- Swiss Federal Commission for Nutrition (Eidgenossische Ernahrungskommission, CH)
- Malformation Monitoring Saxony-Anhalt (Fehlbildungsmonitoring Sachsen-Anhalt)
- Folic Acid Initiative Rheinland Pfalz (Folsaure-Initiative Rheinland Pfalz)
- Foundation Folic Acid Offensive Switzerland (Stiftung Folsaure Offensive Schweiz)
- Register of Births Mainz Model (Geburtenregister Mainzer Modell)
- Society for Applied Vitamin Research (Gesellschaft fur angewandte Vitaminforschung)
- Homocysteine Expert Panel
- Child Health Foundation (Stiftung Kindergesundheit)
- Professional Association of Nutritional Sciences (Berufsverband Oecotrophologie
- VDOE)
Each year approximately 2400 pregnancies develop folic acid-preventable spina bifida and anencephaly in Europe. Currently, 70% of all affected pregnancies are terminated after prenatal diagnosis. The prevalence of neural tube defects (NTDs) has been significantly lowered in more than 70 countries worldwide by applying fortification with folic acid. Periconceptional supplementation of folic acid also reduces the risk of congenital heart diseases, preterm birth, low birth weight, and health problems associated with child mortality and morbidity. All European governments failed to issue folic acid fortification of centrally processed and widely eaten foods in order to prevent NTDs and other unwanted birth outcomes. The estimated average dietary intake of folate in Germany is 200 mu g dietary folate equivalents (DFE)/day. More than half of German women of reproductive age do not consume sufficient dietary folate to achieve optimal serum or red blood cell folate concentrations (>18 or 1000 nmol/L, respectively) necessary to prevent spina bifida and anencephaly. To date, targeted supplementation is recommended in Europe, but this approach failed to reduce the rate of NTDs during the last 10 years. Public health centers for prenatal care and fortification with folic acid in Europe are urgently needed. Only such an action will sufficiently improve folate status, prevent at least 50% of the NTD cases, reduce child mortality and morbidity, and alleviate other health problems associated with low folate such as anemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据