LC and LC-MS/MS studies for identification and characterization of degradation products of d-tubocurarine chloride

Article Education, Scientific Disciplines

Identification and Characterization of in vitro Metabolites of Belinostat by Rat Liver Microsomes using Ultra Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry

Parul Grover et al.

Summary: This study analyzes the in-vitro metabolites of the anticancer drug belinostat and predicts its in-vivo metabolism and detoxification mechanisms based on enzyme kinetic parameters. This research provides valuable insights into the safety, efficacy, elimination mechanism, and effectiveness of belinostat.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Adsorption and Inhibition Analysis of Aconitine and Tubocurarine Alkaloids as Eco-friendly Inhibitors of Pitting Corrosion in ASTM - A47 Low Carbon Steel in HCl Acid Environment

Benedict Ushaka Ugi et al.

Summary: This study investigated the adsorption and inhibition properties of aconitine alkaloid (ACA) and tubocurarine alkaloid (TBA) as eco-friendly inhibitors for pitting corrosion in low carbon steel in HCl acid. The experimental and analytical methods used included gravimetric method, gasometric method, electrochemical impedance spectroscopy, potentiodynamic polarization, and scanning electron microscopy method. The results showed that tubocurarine and aconitine alkaloids were effective inhibitors with inhibition efficiencies of 98.8% and 91.2% at a maximum inhibitor concentration of 1500 ppm, respectively. The electrochemical data supported the efficacy of these inhibitors and their adsorption behavior followed various adsorption isotherms.

INDONESIAN JOURNAL OF CHEMISTRY (2022)

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Article Education, Scientific Disciplines

Development and Validation of Novel and Highly Sensitive Stability-Indicating Reverse Phase UPLC Method for Quantification of Dabrafenib and its ten Degradation Products

Parul Grover et al.

Summary: This study developed a stability-indicating RP-UPLC method for the estimation of dabrafenib and its degradation products. The method is highly sensitive and was successfully applied in forced degradation studies.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction

Elisabeth Wigenstam et al.

Summary: This study utilized an ex vivo rat precision-cut lung slice model to demonstrate improved airway function following nerve agent exposure by adjunct treatment with various drugs. These drugs include muscarinic and adrenergic receptor antagonists, Na+ and K-ATP(+) channel blockers, and Ca2+-channel blockers, showing significant airway relaxation and decreased contractions induced by stimulation.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Chemistry, Analytical

Identification and characterization of forced degradation products of sertraline hydrochloride using UPLC, ultra-high-performance liquid Chromatography-Quadrupole-Time of flight mass spectrometry (UHPLC-Q-TOF/MS/MS) and NMR

Parul Grover et al.

Summary: This study investigated the degradation behavior of sertraline hydrochloride (SRT), a selective serotonin reuptake inhibitor (SSRI), under various stressed conditions. The results showed that SRT was stable under hydrolytic and thermal degradation conditions, but formed five degradation products under oxidative and photolytic conditions.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Chemistry, Analytical

LC-MS/MS studies for identification and characterization of new forced degradation products of dabrafenib and establishment of their degradation pathway

Parul Grover et al.

Summary: Dabrafenib (Tafinlar) is used for the treatment of BRAF V600 mutation positive unresectable or metastatic melanoma. Forced degradation study of dabrafenib was conducted to identify and characterize its major degradation products under various stress conditions. Dabrafenib showed sensitivity to oxidative degradation and photolytic degradation, but remained stable in acidic, alkaline, neutral, and thermal degradation environments. The study identified five major degradation products under oxidative stress and three major degradation products under photolytic degradation, further characterized by HRMS/MS/TOF technique. The degradation pathway of dabrafenib was established with fragmentation pathways of degradation products explained.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Article Chemistry, Analytical

LC and LC-MS/MS studies for identification and characterization of new degradation products of ibrutinib and elucidation of their degradation pathway

Lovekesh Mehta et al.

Summary: Forced degradation studies of ibrutinib drug were conducted in various conditions to identify and characterize degradation products. The drug was found to be highly sensitive to oxidative degradation, alkaline hydrolysis, and acidic hydrolysis at high temperature. A sensitive HRMS/MS/TOF method was developed to identify all ten degradation products formed during stress study, revealing new degradation impurities. The proposed mechanism and pathways of degradation products of ibrutinib were discussed.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Article Pharmacology & Pharmacy