期刊
JOURNAL OF PEPTIDE SCIENCE
卷 22, 期 3, 页码 186-191出版社
WILEY
DOI: 10.1002/psc.2859
关键词
diethylphosphoryl-Glyceroacetonide-Oxyma; Oxyma; segment coupling; lactam-forming reactions; peptide synthesis
资金
- National Institutes of Health (NIAID) [AI084411, AI119796]
- University of Tennessee
- NIH Shared Instrumentation Grants
Glyceroacetonide-Oxyma [(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (1)] displayed remarkable physico-chemical properties as an additive for peptide-forming reactions. Although racemization-free amide-forming reactions have been established for N-urethane-protected -amino acids with EDCI, 1, and NaHCO3 in water or DMF-water media, amide-forming reactions of N-acyl-protected -amino acids and segment couplings of oligopeptides still require further development. Diethylphosphoryl-glyceroacetonide-oxyma (DPGOx 3) exhibits relative stability in aprotic solvents and is an effective coupling reagent for N-acyl-protected -amino acids and oligo peptide segments. The conditions reported here is also effective in lactam-forming reactions. Unlike most of the reported coupling reagents, simple aqueous work-up procedures can remove the reagents and by-products generated in the reactions. Copyright (c) 2016 European Peptide Society and John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据