期刊
JOURNAL OF PEDIATRICS
卷 255, 期 -, 页码 224-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2022.11.026
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The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Improvement in respiratory status, right heart dilation, function, and chronic pulmonary arterial hypertension were observed. There were decreases in systolic, diastolic, and mean arterial pressures, without any critical hypotension or hypoxemia.
The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10), function (n = 9/10), and chronic pulmonary arterial hypertension (n = 8/10) improved. Median decrement in systolic (12 [4, 14]), diastolic (14 [7, 20]), and mean arterial (14 [10, 17]) pressures were noted; no critical hypotension or hypoxemia occurred.
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