4.3 Article

Validation of the IMPACT-III Questionnaire in French Children With Inflammatory Bowel Disease

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPG.0000000000003716

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Crohn disease; pediatric; quality of life; ulcerative colitis

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This study aimed to assess the reliability and validity of the IMPACT-III questionnaire in French children with inflammatory bowel disease. The results showed that the IMPACT-III questionnaire is a reliable and valid instrument for measuring health-related quality of life in this population.
Objectives:This study assessed the reliability and validity of the IMPACT-III questionnaire, a health-related quality of life (HRQoL) instrument, in French children with inflammatory bowel disease (IBD). Methods:Eighty-four children and adolescents (45 boys, aged 14.3 +/- 2.7 years) were included in a validation study of the IMPACT-III questionnaire. Patients completed 2 questionnaires for measuring HRQoL: the IMPACT-III and the Pediatric Quality of Life Inventory 4.0 Generic Core Scale (PedsQL). Internal consistency was assessed using Cronbach alpha. Factor analysis was performed on data from the IMPACT-III to help construct domains. Concurrent validity was assessed by calculating Spearman correlation coefficients. Results:Cronbach alpha for the PedsQL total score was good (0.89). The most robust factor solution was a 3-domain structure: (a) Concerns, (b) Body Image and Physical Condition, and (c) Symptoms and Socializing. All domains had good reliability (0.674-0.863). Only 2 items had to be removed. Discriminant validity was demonstrated by significant differences (P < 0.001) in median IMPACT-III scores between inactive and active disease for the total score (83.3 vs 72.0), and for Concerns (P < 0.002) and Symptoms and Socializing (P < 0.001). Conclusions:These results suggest that IMPACT-III appears to be a useful instrument for measuring HRQoL in French children with IBD.

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