☆ 4.5 Article

Pain Science in Practice (Part 4): Central Sensitization I

JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY (2023)

Pain Science in Practice: Linking Basic Pain Science to the Clinic and Quality Musculoskeletal Rehabilitation Care

Morten Hoegh et al.

JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY (2022)

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Editorial Material Orthopedics

Pain Science in Practice (Part 3): Peripheral Sensitization

M. O. R. T. E. N. HOEGH

Summary: Peripheral sensitization is a crucial factor in inflammation and sensitivity that leads to pain. This editorial explains the principles of peripheral sensitization, neurogenic inflammation, the axon reflex, as well as the role of second messengers and peptidergic C-fibers.

JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY (2022)

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Letter Anesthesiology

Not being able to measure what is important, does not make things we can measure important

Morten Hoegh et al.

PAIN (2022)

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Article Cell Biology

Immune regulation of pain: Friend and foe

Annemieke Kavelaars et al.

Summary: The immune system and peripheral sensory nervous system communicate through shared mediators and receptors, playing both proinflammatory and anti-inflammatory roles. T cells and macrophages can enhance pain sensitivity while also promoting pain resolution.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Anesthesiology

Human surrogate models of central sensitization: A critical review and practical guide

Charles Quesada et al.

Summary: The study conducted a systematic review and meta-analysis of human pain models, identifying five reliable models that induce secondary hyperalgesia and have pharmacological profiles similar to clinical conditions. These models can inform basic research for new drug development by providing helpful potential biomarkers.

EUROPEAN JOURNAL OF PAIN (2021)

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Review Anesthesiology