期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02584
关键词
-
A copper-based system enables the methylene insertion reaction between an amine and a milder nucleophile, such as a terminal alkyne, through the cleavage of the C-N bond in N,N-dimethylacetamide. This method provides a convenient access to propargylic amines with good to excellent yields. The wide substrate scope and the ability to functionalize complex molecules at late stages make this protocol practically valuable.
A copper-based system allows for the methylene insertion between an amine and a milder nucleophile, including a terminal alkyne counterpart, via C-N bond cleavage of N,Ndimethylacetamide. The method gives an expedient access to propargylic amines in good to excellent yields. A wide-ranging substrate scope and late-stage functionalization of complex molecules make the protocol practically valuable.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据