1,4-D-Sorbitan: A Promising Biobased-Platform for the Synthesis of Chiral Amines

The regio-and diastereoselective synthesis of chiral amines derived from 1,4-D-sorbitan has been developed via the borrowing hydrogen reaction using a cooperative catalysis between an achiral iridium catalyst and diphenylphosphoric acid. The different reactivities of the four hydroxyl groups on the 1,4-D- sorbitan scaffold have also been highlighted.

Automated summary

The regio- and diastereoselective synthesis of chiral amines derived from 1,4-D-sorbitan has been achieved through the borrowing hydrogen reaction, using a cooperative catalysis between an achiral iridium catalyst and diphenylphosphoric acid. The differential reactivities of the four hydroxyl groups on the 1,4-D-sorbitan scaffold have also been emphasized.