Divergent Coupling of ortho-Alkynylnaphthols and Benzofurans: [4+2] Cycloaddition and Friedel-Crafts Reaction

Catalytic direct [4 + 2] cycloaddition reactions and Friedel-Crafts reactions of ortho-alkynylnaphthols with benzofurans have been developed, affording functionalized hydrobenzofuro[3,2-b]chromans and hydroarylation products, respectively, in high yields with high chemoselectivity.

Automated summary

Catalytic direct [4 + 2] cycloaddition reactions and Friedel-Crafts reactions of ortho-alkynylnaphthols with benzofurans have been developed. They afford high yields of functionalized hydrobenzofuro[3,2-b]chromans and hydroarylation products, respectively, with high chemoselectivity.