期刊
JOURNAL OF PEDIATRICS
卷 177, 期 -, 页码 133-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2016.06.045
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资金
- Australia's National Health & Medical Research Council
- Centre of Clinical Research Excellence [546519]
- Centre of Research Excellence in Newborn Medicine [1060733, 237117, 491209, 1081288, 1012236, 1053787, 1085754, 1053609]
- National Institutes of Health [HD058056]
- United Cerebral Palsy Foundation (US
- Leila Y. Mathers Charitable Foundation (US)
- Brown Foundation (US)
- Victorian Government's Operational Infrastructure Support Program
- Royal Children's Hospital Foundation
- Cambridge Commonwealth Travelling Bursary (St John's College, Cambridge)
- Mary Euphrasia Mosley and Sir Bartle Frere Fund
- Lord Mayor's 800th Anniversary Awards Trust
- Nichol Young Foundation
- Worts Travelling Scholars' Award
Objectives To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants Study design We studied 180 infants born at < 30 weeks' gestation or < 1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001-2003. We calculated the number of days on which infants received > 50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression. Results A greater number of days on which infants received > 50% breast milk was associated with greater deep nuclear gray matter volume at term equivalent age (0.15 cc/d; 95% CI, 0.05-0.25); and with better performance at age 7 years of age on IQ (0.5 points/d; 95% CI, 0.2-0.8), mathematics (0.5; 95% CI, 0.1-0.9), working memory (0.5; 95% CI, 0.1-0.9), and motor function (0.1; 95% CI, 0.0-0.2) tests. No differences in regional brain volumes at 7 years of age in relation to breast milk intake were observed. Conclusion Predominant breast milk feeding in the first 28 days of life was associated with a greater deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants.
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