Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments

Carbon monoxide is a cheap and abundant C1 building block that can be readily incorporated into organic molecules to rapidly build structural complexity. In this Perspective, we outline several recent (since 2015) examples of palladium-catalyzed carbonylations in streamlining complex natural product total synthesis and highlight the strategic importance of these carbonylation reactions in the corresponding synthesis. The selected examples include spinosyn A, callyspongiolide, perseanol, schizozygane alkaloids, cephanolides, and bisdehydroneostemoninine and related stemona alkaloids. We also provide our perspective about the recent advancements and future developments of palladium-catalyzed carbonylations.

Automated summary

This perspective summarizes several examples of palladium-catalyzed carbonylations since 2015, illustrating their importance in simplifying complex natural product total synthesis and emphasizing their strategic significance in corresponding syntheses. The selected examples include spinosyn A, callyspongiolide, perseanol, schizozygane alkaloids, cephanolides, and bisdehydroneostemoninine and related stemona alkaloids. The perspective also provides insights into recent advancements and future developments of palladium-catalyzed carbonylations.