期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 4, 页码 2655-2665出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c03001
关键词
-
Herein, we report a palladium-catalyzed regioselective C3-allylic alkylation of 2-aryl imidazopyridines with MBH carbonates. This strategy allows for the synthesis of diverse C3-allylated imidazopyridines, and their structures have been confirmed by X-ray analysis. Furthermore, the reaction can be easily scaled up and the resulting product can be manipulated into synthetically useful entities.
Imidazopyridine is an important framework that constitutes several pharmaceutical drugs and biologically active molecules. Herein, we present the palladium-catalyzed regioselective C3-allylic alkylation of 2-aryl imidazopyridines with MBH carbonates. This strategy furnishes a broad spectrum of C3allylated imidazopyridines, and their structures have been unequivocally established using X-ray analysis. Besides, the reaction can be easily scaled up on a gram scale, and the ensuing product can be smoothly manipulated into synthetically useful entities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据