Dual-Catalytic Enantioselective Allylation of N-(Heteroaromatic- methyl)imine Derivatives

We report the dual-catalytic enantioselective allylic alkylation of 2-(pyridylmethyl)amine-derived ketimines with allylic carbonates. The reaction proceeds under mild reaction conditions to generate alpha-amino heteroaryl benzylamine stereocenters in good yield and enantioselectivity. Enantioselectivity is achieved through the use of a copper catalyst modified with chiral bisphosphine ligand (2S,4S)-bis(diphenylphosphino)pentane.

Automated summary

We report a dual-catalytic enantioselective allylic alkylation reaction that allows for the synthesis of alpha-amino heteroaryl benzylamine stereocenters with high yield and enantioselectivity.