Synthesis of C4-Aminated Carbazoles and Their Derivatives via Pd/NBE Chemistry

Carbazole, as one of the most important organic frameworks, has been used in optoelectronic materials and biochemistry. However, the synthesis of C4-substituted carbazole has always been an unsolved problem. This report describes the one-step synthesis of C4-aminated carbazoles and their derivatives through the series reaction of C-H amination and arylation. The substrate scope is wide. C4-Amino carbazoles substituted by C2, C6, C7, and C8 methyl groups, especially carbazole derivatives of fused rings, pyridine, and dibenzofuran, can be synthesized.

Automated summary

This report presents a one-step synthesis of C4-aminated carbazoles and their derivatives through a series reaction of C-H amination and arylation. The substrate scope is wide, allowing for the synthesis of C4-amino carbazoles substituted by C2, C6, C7, and C8 methyl groups, as well as carbazole derivatives of fused rings, pyridine, and dibenzofuran.