期刊
JOURNAL OF NON-CRYSTALLINE SOLIDS
卷 600, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jnoncrysol.2022.122018
关键词
Mg-MOF-74; Core-shell structure; Stability; Mesoporous silica; Slow release
The core-shell structure of Mg-MOF-74@MSiO2 was successfully synthesized using the sol-gel method, with the shell mainly composed of mesoporous silica. Under the protection of the mesoporous silica shell, the release rate of Mg2+ from Mg-MOF-74 in a simulated physiological environment was slowed down, leading to improved stability. The cytotoxicity analysis showed that Mg-MOF-74@MSiO2 had no cytotoxic effects and even had a better effect on promoting BMSCs cell proliferation compared to Mg-MOF-74. Therefore, Mg-MOF-74@MSiO2 has great potential for use in scaffold materials for bone repair, and the strategy used to improve stability is also universally significant for other MOF materials.
To improve the stability of Mg-MOF-74 in physiological water environment and enhance its biomedical func-tions, XRD, FTIR, SEM-EDS, BET and TEM characterization confirmed that the core-shell structure of Mg-MOF-74@MSiO2 was successfully synthesized by sol-gel method, and the shell was mainly composed of mesoporous silica with a pore size of 2.0-2.5 nm and a thickness of about 40 nm. ICP-OES test showed that under the protection of mesoporous silica shell, the Mg2+ release rate in simulated physiological environment of Mg-MOF-74 slowed down, that is, the stability of Mg-MOF-74 was improved. Furthermore, the cytotoxicity analysis confirmed that Mg-MOF-74@MSiO2 had no cytotoxicity, and even showed better effect on promoting BMSCs cell proliferation than Mg-MOF-74. Therefore, Mg-MOF-74@MSiO2 has good application potential in scaffold ma-terials for bone repair. Moreover, our strategy of improving stability is also of universal significance to other MOF materials.
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