4.7 Article

Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Optics

Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window

Shubham Mirg et al.

Summary: This article proposes a transparent ultrasound transducer (TUT) based on lithium niobate as a cranial window for thinned mouse skull, which can be used for optical resolution photoacoustic microscopy (OR-PAM) imaging and other applications.

OPTICS LETTERS (2022)

Article Biology

Pupil diameter is not an accurate real-time readout of locus coeruleus activity

Marine Megemont et al.

Summary: Pupil diameter is often used as a noninvasive measure of locus coeruleus (LC) activity. However, there is substantial variability in the relationship between pupil diameter and LC activity, limiting its accuracy in predicting LC activity. Additionally, pupil responses to optical stimulation in the LC show session-to-session fluctuations, and these variations are correlated with decision bias-related behavioral variables.
Article Neurosciences

Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide

Qingguang Zhang et al.

Summary: This article discusses the importance of monitoring behavioral state in imaging experiments using unanesthetized rodents and describes how to incorporate detailed behavioral and physiological measurements. The effects of movements and sleep-related signals on brain hemodynamics and electrophysiological signals are summarized, with guidance on integrating these measurements into functional brain imaging and electrophysiology. The article provides a how-to guide on monitoring and interpreting physiological signals in awake behaving mice for neurovascular coupling experiments, aiming to facilitate neuroimaging in awake animal models.

NEUROPHOTONICS (2022)

Review Neurosciences

Pupillometry as an integrated readout of distinct attentional networks

Christoph Strauch et al.

Summary: The process of pupillary constriction and dilation can provide an accessible, affordable, and non-invasive measure of brain activity. A new taxonomy is proposed to understand the factors affecting pupil size and their neural underpinnings. Pupil size serves as an integrated measure of different attentional states.

TRENDS IN NEUROSCIENCES (2022)

Article Multidisciplinary Sciences

A unified model of the task-evoked pupil response

Charlie S. Burlingham et al.

Summary: The dilation and constriction of the pupil following task events can be explained by a model based on the common neural input driving saccades and pupil size. The estimates of arousal from this model are consistent with key predictions and offer a unified explanation for a wide range of phenomena.

SCIENCE ADVANCES (2022)

Article Neurosciences

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

Ravi Teja Kedarasetti et al.

Summary: The movement of fluid in and out of the brain plays a vital role in clearing metabolic waste. This research investigates the mechanisms behind fluid movement and suggests that arteriolar dilations can drive fluid circulation in the brain, especially during sleep-like conditions. The study highlights the importance of convective flow in the extracellular space for waste clearance.

FLUIDS AND BARRIERS OF THE CNS (2022)

Review Hematology

Photoacoustic imaging for microcirculation

Shubham Mirg et al.

Summary: Microcirculation plays a crucial role in maintaining tissue health, and photoacoustic imaging (PAI) is an effective technique for imaging microvascular networks and obtaining quantitative information about blood dynamics. PAI is of great clinical relevance in neurovascular, cardiovascular, ophthalmic, and cancer research fields. However, there are still challenges and limitations that need to be addressed in PAI.

MICROCIRCULATION (2022)

Article Neurosciences

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Celia Kjaerby et al.

Summary: Kjaerby and Andersen et al. demonstrate the important role of norepinephrine (NE) in shaping sleep micro-architecture. NE oscillates during sleep and its amplitude affects memory consolidation and awakenings. Micro-arousals are generated in a periodic pattern during NREM sleep, while NE oscillations drive spindles. The amplitude of NE oscillations plays a crucial role in sleep micro-architecture and memory performance.

NATURE NEUROSCIENCE (2022)

Article Multidisciplinary Sciences

A cognitive process occurring during sleep is revealed by rapid eye movements

Yuta Senzai et al.

Summary: The eye movements during REM sleep reveal the gaze shifts in the virtual world of dreams, providing insight into the cognitive processes of the sleeping brain.

SCIENCE (2022)

Article Neurosciences

Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability

Qingqing Zhang et al.

Summary: The study reveals that ongoing brain-wide activity plays a significant role in the cross-trial variability of task-based functional magnetic resonance imaging (fMRI). Removing this ongoing activity can reduce the variability of the fMRI response and improve its coherence with neuronal activity.

CEREBRAL CORTEX (2022)

Article Biochemistry & Molecular Biology

Noradrenergic circuit control of non-REM sleep substates

Alejandro Osorio-Forero et al.

Summary: During NREMS, fluctuation of noradrenaline levels in thalamus are associated with sleep spindle rhythms and heart-rate variations, indicating vigilance-promoting mechanism by LC neurons. Optogenetic activation or inhibition of LC neurons can modulate sleep-spindle clustering and heart-rate variations, affecting sensory arousability during NREMS. Noradrenergic modulation of thalamic circuits plays a key role in maintaining sensory arousability in mammalian NREMS.

CURRENT BIOLOGY (2021)

Article Multidisciplinary Sciences

Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state

Shawn R. Gray et al.

Summary: Recent studies have shown that arousal state plays a crucial role in sensory processing and attention. Specifically, arousal controls brain-wide neural activity patterns, largely through modulation by norepinephrine. Surprisingly, low-intensity, nonarousing visual stimuli were found to enhance vigilance-dependent noradrenergic signaling locally in the visual cortex.

SCIENCE ADVANCES (2021)

Article Biology

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task

Hongdian Yang et al.

Summary: In mice performing a tactile detection task, the relationships between locus coeruleus (LC) activity, primary somatosensory cortex (S1) activity, and pupil diameter are complex and vary on different timescales. Pupil diameter may not accurately reflect LC activity and cannot be used as a consistent index for LC activity.
Article Biology

Standardized and reproducible measurement of decision-making in mice

Valeria Aguillon-Rodriguez et al.

Summary: Research on measuring mouse behavior has yielded reproducible results across multiple laboratories, showing that once training is complete, there are no significant differences in behavior across labs. Additionally, mice in different labs adopted similar strategies for decision-making.
Article Biology

Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

Filip Sobczak et al.

Summary: Pupil dynamics serve as a physiological indicator of cognitive processes and arousal states of the brain in diverse behavioral experiments. By decomposing spatiotemporal patterns of resting-state fMRI using PCA and optimizing the PCA component weighting via decoding methods, unique activity patterns related to pupil diameter changes in different trials can be studied in relation to neuromodulatory centers. This novel PCA-based decoding method demonstrates the tight coupling between pupil dynamics and different neuromodulatory centers across trials.
Review Neurosciences

Arousal and sleep circuits

Barbara E. Jones

NEUROPSYCHOPHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording

Patricia Pais-Roldan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

Hanna Hayat et al.

SCIENCE ADVANCES (2020)

Article Biochemical Research Methods

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

Mattia Privitera et al.

NATURE PROTOCOLS (2020)

Article Multidisciplinary Sciences

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

Ravi Teja Kedarasetti et al.

SCIENTIFIC REPORTS (2020)

Article Biochemical Research Methods

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Miao Jing et al.

NATURE METHODS (2020)

Review Neurosciences

Locus coeruleus: a new look at the blue spot

Gina R. Poe et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Neurosciences

Functional hyperemia drives fluid exchange in the paravascular space

Ravi Teja Kedarasetti et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

Article Multidisciplinary Sciences

Spontaneous behaviors drive multidimensional, brainwide activity

Carsen Stringer et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

Task-related hemodynamic responses are modulated by reward and task engagement

Mariana M. B. Cardoso et al.

PLOS BIOLOGY (2019)

Article Neurosciences

Single-trial neural dynamics are dominated by richly varied movements

Simon Musall et al.

NATURE NEUROSCIENCE (2019)

Review Clinical Neurology

Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity

Patrick J. Drew et al.

NEUROSCIENTIST (2019)

Article Multidisciplinary Sciences

Cerebral oxygenation during locomotion is modulated by respiration

Qingguang Zhang et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Pupil Size Coupling to Cortical States Protects the Stability of Deep Sleep via Parasympathetic Modulation

Ozge Yuzgec et al.

CURRENT BIOLOGY (2018)

Review Neurosciences

Neuromodulatory Correlates of Pupil Dilation

Rylan S. Larsen et al.

FRONTIERS IN NEURAL CIRCUITS (2018)

Article Multidisciplinary Sciences

Subcortical evidence for a contribution of arousal to fMRI studies of brain activity

Xiao Liu et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

The pial vasculature of the mouse develops according to a sensory-independent program

Matthew D. Adams et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

Alexander Mathis et al.

NATURE NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep

Antoine Bergel et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Wake-sleep circuitry: an overview

Clifford B. Saper et al.

CURRENT OPINION IN NEUROBIOLOGY (2017)

Article Neurosciences

Local and global contributions to hemodynamic activity in mouse cortex

M. Andrea Pisauro et al.

JOURNAL OF NEUROPHYSIOLOGY (2016)

Review Multidisciplinary Sciences

Circuit-based interrogation of sleep control

Franz Weber et al.

NATURE (2016)

Review Biology

Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches

Ying Ma et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Article Multidisciplinary Sciences

Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons

Ying Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

Jacob Reimer et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light

Violetta Pilorz et al.

PLOS BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Organization of the Locus Coeruleus-Norepinephrine System

Lindsay A. Schwarz et al.

CURRENT BIOLOGY (2015)

Article Neurosciences

fMRI Cortical Correlates of Spontaneous Eye Blinks in the Nonhuman Primate

Olivier Guipponi et al.

CEREBRAL CORTEX (2015)

Review Neurosciences

Cortical Control of Whisker Movement

Carl C. H. Petersen

ANNUAL REVIEW OF NEUROSCIENCE, VOL 37 (2014)

Article Neurosciences

Pupil Diameter Covaries With BOLD Activity in Human Locus Coeruleus

Peter R. Murphy et al.

HUMAN BRAIN MAPPING (2014)

Article Endocrinology & Metabolism

Determination of vessel cross-sectional area by thresholding in Radon space

Yu-Rong Gao et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Neurosciences

Comparison of Sleep Spindles and Theta Oscillations in the Hippocampus

David Sullivan et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Neurosciences

Neurovascular Coupling and Decoupling in the Cortex during Voluntary Locomotion

Bing-Xing Huo et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Neurosciences

Fast Hemodynamic Responses in the Visual Cortex of the Awake Mouse

M. Andrea Pisauro et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Neurosciences

Cellular mechanisms of brain state-dependent gain modulation in visual cortex

Pierre-Olivier Polack et al.

NATURE NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Blink-related momentary activation of the default mode network while viewing videos

Tamami Nakano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie et al.

SCIENCE (2013)

Article Endocrinology & Metabolism

The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand

Lane K. Bekar et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Neurosciences

Rational regulation of learning dynamics by pupil-linked arousal systems

Matthew R. Nassar et al.

NATURE NEUROSCIENCE (2012)

Article Neurosciences

A BOLD signature of eyeblinks in the visual cortex

Jean-Michel Hupe et al.

NEUROIMAGE (2012)

Article Neurosciences

Tonic and phasic components of eye movements during REM sleep in the rat

Alvaro Sanchez-Lopez et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2011)

Article Neurosciences

Chromatic Bipolar Cell Pathways in the Mouse Retina

Tobias Breuninger et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Neurosciences

Characterizing the Spontaneous Blink Generator: An Animal Model

Jaime Kaminer et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Neurosciences

Pupil dilation signals surprise: evidence for noradrenaline's role in decision making

Kerstin Preuschoff et al.

FRONTIERS IN NEUROSCIENCE (2011)

Article Behavioral Sciences

Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function

Mark S. Gilzenrat et al.

COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE (2010)

Article Neurosciences

Pupil dilation betrays the timing of decisions

Einhäuser

Frontiers in Human Neuroscience (2010)

Article Biochemical Research Methods

Chronux: A platform for analyzing neural signals

Hemant Bokil et al.

JOURNAL OF NEUROSCIENCE METHODS (2010)

Article Biochemical Research Methods

Chronic optical access through a polished and reinforced thinned skull

Patrick J. Drew et al.

NATURE METHODS (2010)

Article Neurosciences

Tuning arousal with optogenetic modulation of locus coeruleus neurons

Matthew E. Carter et al.

NATURE NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity

Yevgeniy B. Sirotin et al.

NATURE (2009)

Review Neurosciences

The genetic and molecular regulation of sleep: from fruit flies to humans

Chiara Cirelli

NATURE REVIEWS NEUROSCIENCE (2009)

Article Neurosciences

Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep

Sean M. Montgomery et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Psychology, Biological

The pupil as a measure of emotional arousal and autonomic activation

Margaret M. Bradley et al.

PSYCHOPHYSIOLOGY (2008)

Review Neurosciences

The functional organization of the barrel cortex

Carl C. H. Petersen

NEURON (2007)

Review Physiology

Perivascular nerves and the regulation of cerebrovascular tone

E Hamel

JOURNAL OF APPLIED PHYSIOLOGY (2006)

Article Neurosciences

Two distinct neural effects of blinking on human visual processing

D Bristow et al.

NEUROIMAGE (2005)

Article Biochemistry & Molecular Biology

Blinking suppresses the neural response to unchanging retinal stimulation

D Bristow et al.

CURRENT BIOLOGY (2005)

Article Behavioral Sciences

Eye activity correlates of workload during a visuospatial memory task

KF Van Orden et al.

HUMAN FACTORS (2001)

Article Neurosciences

Pupillary response to chromatic flicker

P Drew et al.

EXPERIMENTAL BRAIN RESEARCH (2001)

Article Neurosciences

Activity of primate V1 cortical neurons during blinks

TJ Gawne et al.

JOURNAL OF NEUROPHYSIOLOGY (2000)