4.7 Article

Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway

Hengjiang Guo et al.

Summary: The study found that ZFP36 protects against neuronal injury induced by OGD/R by inhibiting NOX4-mediated DRP1 activation and excessive mitochondrial fission. Targeting ZFP36 pharmacologically may provide new therapeutic strategies for treating cerebral I/R injury.

BRAIN RESEARCH BULLETIN (2022)

Article Cell Biology

RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation

Wen Geng et al.

Summary: The study showed that the RPL41 peptide decreased the viability, migration, and invasion of retinoblastoma cells, promoted apoptosis and cell cycle arrest, and enhanced the antitumor effect of carboplatin. RPL41 sensitized retinoblastoma cells to carboplatin, indicating a potential adjuvant therapy for retinoblastoma.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Cell Biology

LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells

Minmin Xiong et al.

Summary: DANCR plays a critical role in Doxorubicin-induced apoptosis by interacting with QK to enhance the expression of MALAT1 in colorectal cancer cells. Through modulation of RNA stability, DANCR and QK jointly suppress the process of apoptosis.

CELL DEATH & DISEASE (2021)

Article Genetics & Heredity

Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2

Xiliang Wang et al.

Summary: This study systematically evaluated the features and limitations of two frequently used single-cell RNA sequencing platforms, 10X Genomics Chromium and Smart-seq2, by comparing their data generated from the same CD45(-) cell samples. Smart-seq2 detected more genes in a cell, especially low abundance and alternatively spliced transcripts, while 10X-based data showed more severe dropout problems but could detect rare cell types. The study provides insights into the characteristics of these technologies and their applications in single-cell transcriptomics.

GENOMICS PROTEOMICS & BIOINFORMATICS (2021)

Review Cell Biology

Endocannabinoid Metabolism and Traumatic Brain Injury

Dexiao Zhu et al.

Summary: Endocannabinoids play a crucial role in TBI-induced AD, with the inhibition of 2-AG metabolism helping to alleviate neuropathology and improve cognitive function.
Article Neurosciences

Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease

Jack Hashem et al.

Summary: Research suggests that MAGL may be a promising therapeutic target for Alzheimer's disease. Inhibiting MAGL could reduce inflammation, phosphorylated tau proteins, and improve spatial learning and memory retention in tau transgenic mice.

MOLECULAR NEUROBIOLOGY (2021)

Article Biochemical Research Methods

Method of Microglial DNA-RNA Purification from a Single Brain of an Adult Mouse

Md. Obayed Raihan et al.

Summary: Microglia, the resident immune cells in the brain, show dynamic activation level changes in neuropsychiatric diseases, making them a potential therapeutic target. Investigating genetic modifications of individual cells through single-cell molecular biology studies can help understand complex gene regulatory pathways. Isolating sufficient purified microglia from a single brain for DNA and RNA extraction remains challenging, and standardized cell isolation techniques are essential for data comparison.

METHODS AND PROTOCOLS (2021)

Review Genetics & Heredity

Deciphering cell-cell interactions and communication from gene expression

Erick Armingol et al.

Summary: Intercellular interactions and communication can be inferred from RNA sequencing data, such as ligand-receptor pairs, which has led to new insights and methodologies for studying cell-cell interactions.

NATURE REVIEWS GENETICS (2021)

Article Behavioral Sciences

Interleukin-1? in the ventral hippocampus increases stress vulnerability and inflammation-related processes

Jiah Pearson-Leary et al.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2020)

Article Biochemical Research Methods

NicheNet: modeling intercellular communication by linking ligands to target genes

Robin Browaeys et al.

NATURE METHODS (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Article Biochemistry & Molecular Biology

Enzymatic Dissociation Induces Transcriptional and Proteotype Bias in Brain Cell Populations

Daniele Mattei et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Microglial control of astrocytes in response to microbial metabolites

Veit Rothhammer et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

Ana Gil-Ordonez et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Abiy D. Woldetsadik et al.

FASEB JOURNAL (2017)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Article Multidisciplinary Sciences

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

Jung-A A. Woo et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation

Gernot F. Grabner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cell Biology

Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells

Mingfeng He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Interleukin-1 and brain inflammation

David Brough et al.

IUBMB LIFE (2015)

Article Biochemistry & Molecular Biology

beta 2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

Lucas K. Smith et al.

NATURE MEDICINE (2015)

Editorial Material Cell Biology

Homeostatic regulation of brain functions by endocannabinoid signaling

Chu Chen

NEURAL REGENERATION RESEARCH (2015)

Article Cell Biology

The Chemokine System in Innate Immunity

Caroline L. Sokol et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Clinical Neurology

Endocannabinoids in Synaptic Plasticity and Neuroprotection

Jian-Yi Xu et al.

NEUROSCIENTIST (2015)

Article Chemistry, Multidisciplinary

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

Gloria Hernandez-Torres et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Pharmacology & Pharmacy

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

Daniel J. Hermanson et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Review Medicine, Research & Experimental

Therapeutic potential of monoacylglycerol lipase inhibitors

Melinda M. Mulvihill et al.

LIFE SCIENCES (2013)

Review Neurosciences

Multiple Functions of Endocannabinoid Signaling in the Brain

Istvan Katona et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 35 (2012)

Review Pharmacology & Pharmacy

The solute carrier 6 family of transporters

Stefan Broeer et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Cell Biology

Molecular insights on context-specific role of profilin-1 in cell migration

Zhijie Ding et al.

CELL ADHESION & MIGRATION (2012)

Article Cell Biology

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

Rongqing Chen et al.

CELL REPORTS (2012)

Article Pharmacology & Pharmacy

Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ

Huizhi Du et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

Ulrike Taschler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices

Yan Zhou et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Immunology

CCL2/MCP-1 modulation of microglial activation and proliferation

Ara E. Hinojosa et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Article Multidisciplinary Sciences

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

Daniel K. Nomura et al.

SCIENCE (2011)

News Item Biochemistry & Molecular Biology

LIPIDS COX-2's new role in inflammation

Chu Chen

NATURE CHEMICAL BIOLOGY (2010)

Review Neurosciences

Neuroinflammation and Memory: The Role of Prostaglandins

Amy M. Hein et al.

MOLECULAR NEUROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation

Jian Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

Jacqueline L. Blankman et al.

CHEMISTRY & BIOLOGY (2007)

Article Behavioral Sciences

Transthyretin influences spatial reference memory

Joao Carlos Sousa et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2007)

Article Cell Biology

Role of c-Fos/JunD in protecting stress-induced cell death

H. Zhou et al.

CELL PROLIFERATION (2007)

Article Biochemistry & Molecular Biology

Endocannabinoids and β-amyloid-induced neurotoxicity in vivo:: effect of pharmacological elevation of endocannabinoid levels

M. van der Stelt et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Neurosciences

Expression of cystatin C prevents oxidative stress-induced death in PC 12 cells

K Nishiyama et al.

BRAIN RESEARCH BULLETIN (2005)

Review Neurosciences

Cannabinoid signaling in glial cells

N Stella

Article Multidisciplinary Sciences

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury

D Panikashvili et al.

NATURE (2001)