4.7 Article

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Critical Care Medicine

Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder

Kaitlin M. Best et al.

Summary: Traumatic brain injury (TBI) is associated with chronic pain and substance use disorder (SUD), but the mechanisms underlying these conditions are not well understood. Dynorphin and its receptor KOR play important roles in chronic pain and SUD. This review highlights the potential involvement of dynorphin in long-term sequelae after TBI and identifies similarities between the pathophysiology of chronic pain, SUD, and TBI.

JOURNAL OF NEUROTRAUMA (2022)

Review Clinical Neurology

The role of IL-6 in TBI and PTSD, a potential therapeutic target?

Molly Monsour et al.

Summary: This literature review examines the role of IL-6 in neuroinflammation induced by TBI or PTSD, suggesting that targeting IL-6 at specific time points may be beneficial in modulating neuroinflammation and reducing its impact on cognition.

CLINICAL NEUROLOGY AND NEUROSURGERY (2022)

Article Critical Care Medicine

Satisfaction with Life after Mild Traumatic Brain Injury: A TRACK-TBI Study

Stephanie D. Agtarap et al.

Summary: The study identified emotional post-TBI symptoms, anhedonia, and pain interference as important predictors of lower life satisfaction following mild TBI. Insomnia and negative affect also predicted lower life satisfaction at specific time points. Tailoring evidence-based treatments for affective symptoms, pain, and insomnia may be beneficial in improving life satisfaction after mTBI.

JOURNAL OF NEUROTRAUMA (2021)

Article Critical Care Medicine

Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment

Abigail G. Schindler et al.

Summary: Repetitive mild traumatic brain injury has been identified as a significant issue among military service members, often associated with PTSD. Using a mouse model of blast, researchers found that repetitive blast exposure led to chronic aversive responses, while single exposure only produced acute stress responses. This highlights the complexity of repetitive blast exposure and supports the use of animal modeling in understanding the mechanisms behind it.

JOURNAL OF NEUROTRAUMA (2021)

Article Behavioral Sciences

Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice

Britahny Baskin et al.

Summary: Repetitive blast exposure in male mice was found to increase reward-seeking and goal-directed behavior while decreasing behavioral flexibility, with concurrent chronic adverse behavioral changes related to anxiety, compulsivity, and hyperarousal. These findings suggest that deficits in executive function post-blast mTBI may be linked to enhanced compulsivity/hyperreactivity and behavioral inflexibility.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)

Article Substance Abuse

Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans

Abigail G. Schindler et al.

Summary: Research showed that both single and repetitive blast-induced mild traumatic brain injury (mTBI) can affect ethanol-induced behavioral and physiological outcomes. Repetitive blast-induced mTBI may increase the risk of alcohol abuse.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2021)

Article Neurosciences

Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition

Antony D. Abraham et al.

Summary: Dynorphin release in the medial prefrontal cortex disrupts cognitive function via activation of kappa opioid receptors, suggesting a potential mechanism for relapse in opioid-dependent individuals. Targeting kappa opioid receptors in the prefrontal cortex may offer a potential strategy to promote abstinence from opioid dependence.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Clinical Neurology

Reduced Levels of Intestinal Neuropeptides and Neurotrophins in Neurotoxin-Induced Parkinson Disease Mouse Models

Jin Gyu Choi et al.

Summary: The study found that the expression of CCK, Dyn A, and BDNF was significantly reduced in the colon of PD animal models, suggesting that these proteins may play a role in the gut-brain axis in PD.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2021)

Review Pharmacology & Pharmacy

Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors

Angelica del Pilar Escobar et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Immunology

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control

Halina Machelska et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Clinical Neurology

Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain Injury

Joseph T. McCabe et al.

FRONTIERS IN NEUROLOGY (2020)

Article Neurosciences

Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain

Shiwei (Steve) Liu et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Pharmacology & Pharmacy

Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation

Charles Chavkin et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Clinical Neurology

Sensory Sensitivity in TBI: Implications for Chronic Disability

Megan L. Callahan et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Review Clinical Neurology

Untangling PTSD and TBI: Challenges and Strategies in Clinical Care and Research

Rebecca C. Hendrickson et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Review Immunology

Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review

Kathryn Speer et al.

JOURNAL OF INFLAMMATION RESEARCH (2018)

Article Clinical Neurology

Traumatic Brain Injury in Iraq and Afghanistan Veterans: New Results From a National Random Sample Study

Lisa K. Lindquist et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2017)

Article Multidisciplinary Sciences

Peroxiredoxin 6 mediates Gai protein-coupled receptor inactivation by cJun kinase

Selena S. Schattauer et al.

NATURE COMMUNICATIONS (2017)

Article Psychology, Clinical

KAPPA-OPIOID ANTAGONISTS FOR PSYCHIATRIC DISORDERS: FROM BENCH TO CLINICAL TRIALS

William A. Carlezon et al.

DEPRESSION AND ANXIETY (2016)

Article Cell Biology

Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction

James S. Meabon et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Chemistry, Multidisciplinary

The role of the dynorphin/κ opioid receptor system in anxiety

Ai Hang et al.

ACTA PHARMACOLOGICA SINICA (2015)

Article Neurosciences

Discriminating military and civilian traumatic brain injuries

Matthew W. Reid et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2015)

Article Neurosciences

Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

Elena H. Chartoff et al.

FRONTIERS IN NEUROSCIENCE (2015)

Review Clinical Neurology

Factors Associated with Mild Traumatic Brain Injury in Veterans and Military Personnel: A Systematic Review

Maya E. O'Neil et al.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2014)

Review Pharmacology & Pharmacy

Does the kappa opioid receptor system contribute to pain aversion?

Catherine M. Cahill et al.

FRONTIERS IN PHARMACOLOGY (2014)

Article Integrative & Complementary Medicine

Warming Moxibustion Relieves Chronic Visceral Hyperalgesia in Rats: Relations to Spinal Dynorphin and Orphanin-FQ System

Li Qi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Review Clinical Neurology

Blast-related traumatic brain injury

Jeffrey V. Rosenfeld et al.

LANCET NEUROLOGY (2013)

Review Neurosciences

Role of kappa-opioid receptors in stress and anxiety-related behavior

Ashlee Van't Veer et al.

PSYCHOPHARMACOLOGY (2013)

Article Critical Care Medicine

Blast-Induced Tinnitus and Hearing Loss in Rats: Behavioral and Imaging Assays

Johnny C. Mao et al.

JOURNAL OF NEUROTRAUMA (2012)

Article Critical Care Medicine

Lateralized Response of Dynorphin A Peptide Levels after Traumatic Brain Injury

Zubair Muhammad Hussain et al.

JOURNAL OF NEUROTRAUMA (2012)

Article Pharmacology & Pharmacy

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Thomas A Munro et al.

BMC Pharmacology & Toxicology (2012)

Article Clinical Neurology

A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral Characterization

Vassilis E. Koliatsos et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Review Neurosciences

Kinase cascades and ligand-directed signaling at the kappa opioid receptor

Michael R. Bruchas et al.

PSYCHOPHARMACOLOGY (2010)

Article Clinical Neurology

Traumatic Brain Injury Screening: Preliminary Findings in a US Army Brigade Combat Team

Heidi Terrio et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2009)

Article Neurosciences

The dysphoric component of stress is encoded by activation of the dynorphin κ-opioid system

Benjamin B. Land et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Medicine, General & Internal

Mild traumatic brain injury in US Soldiers returning from Iraq

Charles W. Hoge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Biochemistry & Molecular Biology

Long-acting κ opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

Michael R. Bruchas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Clinical Neurology

Hypopituitarism following traumatic brain injury (TBI)

Amar Agha et al.

BRITISH JOURNAL OF NEUROSURGERY (2007)

Review Biochemistry & Molecular Biology

Pathobiology of dynorphins in trauma and disease

KF Hauser et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2005)

Article Medicine, Research & Experimental

Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction

JB Redell et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2003)