期刊
JOURNAL OF PEDIATRICS
卷 171, 期 -, 页码 90-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2015.12.061
关键词
-
类别
资金
- Taiwan National Science Council [NSC 96-2314-B-037-041-MY3, NSC99-2314-B-037-046-MY3, NSC 102-2314-B-037-060]
- Taiwan Ministry of Science and Technology (MOST) [103-2314-B-037-019-MY3]
- Kaohsiung Medical University Aim for the Top Universities Grant [KMU-TP104A13]
- Kaohsiung Medical University Hospital research foundation [KMUH 99-9R29, KMUH 100-0R26, KMUH 101-1R28, KMHK-102-035, KMUH 103-3M59]
Objective To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents. Study design Adolescents (n = 1454, aged 12-16 years) were assessed in a study conducted to monitor Multilevel Risk Profiles for Adolescent Metabolic Syndrome in Taiwan. Detailed information about demographics, diet, physical, anthropometric, and clinical variables was collected. An original homeostatic model assessment of IR (HOMA1-IR), updated nonlinear homeostatic model assessment of IR (HOMA2-IR) model, and several IR markers were measured. Results Adolescents who consumed a greater amount of SSBs were more likely to have elevated fasting serum insulin, HOMA1-IR, and HOMA2-IR (P for trends, <=.028). Compared with SSB nondrinkers, those with >350 mL/d intake of heavy high-fructose corn syrup-containing SSBs had a 0.52 and 0.30 higher multivariate-adjusted HOMA1-IR and HOMA2-IR, respectively. Waist circumference and serum uric acid were correspondingly found to explain 25.4% and 23.6%, as well as 23.2% and 20.6%, of the increases in the 2 IR markers. Both the elevations of HOMA1-IR and HOMA2-IR for high-fructose corn syrup-rich SSB intake were strengthened among obese adolescents (P for interaction, <=.033). Conclusions Fructose-rich SSB intake is associated with elevated levels of IR, and this relationship may be partially mediated by central adiposity and serum uric acid. Obesity may modify the effect of this type of SSB consumption in intensifying the elevation of IR in adolescents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据