4.5 Article

A single protective polymorphism in the prion protein blocks cross-species prion replication in cultured cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Primary glia cells from bank vole propagate multiple rodent-adapted scrapie prions

Karla A. Schwenke et al.

Summary: Animal models have played an important role in prion research, but ethical concerns, cost, and labor-saving aspects have led to the search for alternatives in vitro. Bank voles show unique susceptibility to prions from various species, making them a valuable cell model for studying and comparing different prion strains with diverse species backgrounds.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells

Stefanie-Elisabeth Heumueller et al.

Summary: This translation provides an overview of the characteristics of prion invasion, replication, and dissemination, highlighting the unconventional nature of prions and their reliance on host cell machinery.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Clinical Neurology

Cryo-EM structures of prion protein filaments from Gerstmann-Straussler-Scheinker disease

Grace Hallinan et al.

Summary: The aggregation of Prion protein (PrP) and formation of PrP amyloid (APrP) are crucial events in the development of prion diseases. Gerstmann-Straussler-Scheinker (GSS) disease, a dominantly inherited form of prion protein amyloidosis, is characterized by the presence of PrP amyloid plaques throughout the brain. Cryo-EM analysis of APrP filaments isolated from GSS patients with the F198S mutation revealed their complex structure, highlighting the importance of understanding filament structures in human neurodegenerative diseases.

ACTA NEUROPATHOLOGICA (2022)

Article Multidisciplinary Sciences

2.7 Å cryo-EM structure of ex vivo RML prion fibrils

Szymon W. Manka et al.

Summary: The high-resolution structure of mammalian prions has been determined using cryo-EM, revealing a common architecture among different animal species. These findings provide important insights into the propagation of prions and the differences between different prion strains.

NATURE COMMUNICATIONS (2022)

Article Microbiology

A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants

Laura Pirisinu et al.

Summary: Prions are infectious agents that misfold cellular prion protein (PrP(C)) into infectious aggregates (PrPSc), causing fatal neurodegenerative diseases. The transmission of prions depends on the recipient's PrP(C) sequence and the incoming prion strain. Nor98/atypical scrapie (AS) is a less contagious prion disease compared to classical scrapie (CS), and the relationship between AS and CS strains is still unknown. The study found that the M109I polymorphism affects the susceptibility to AS, and AS isolates in different species encoded the same strain. Additionally, minor CS-like strain components were found in AS isolates.

PLOS PATHOGENS (2022)

Article Microbiology

Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy

Alicia Otero et al.

Summary: In this study, the effect of glycosylation on the characteristics of BSE isolates was assessed using a non-glycosylated human PrPC-expressing mouse model. The findings showed that BSE prions could be propagated in a non-glycosylated human PrPC environment without losing their strain properties. BSE prions transmitted to the transgenic mouse model exhibited neuropathological and biochemical signs compatible with BSE, confirming that the glycosylation of human PrPC is not essential for the propagation of this particular prion strain.

PLOS PATHOGENS (2022)

Article Multidisciplinary Sciences

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

Sudheer Babu Sangeetham et al.

Summary: This study analyzed the impact of the G127V variant of human PrP on the dimerization of PrP, showing that G127V inhibits dimer formation of PrP, though this was not confirmed in a more complex cellular system.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

The aminoglycoside G418 hinders de novo prion infection in cultured cells

Hamza Arshad et al.

Summary: The study found that the antibiotic G418 interferes with the ability of stably transfected cultured cells to become infected with prions, suggesting a selective interference with de novo prion infection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

High-resolution structure and strain comparison of infectious mammalian prions

Allison Kraus et al.

Summary: The study reveals the core structure of prions and the templating surface formed by individual monomers at fibril ends. Comparison to another prion strain shows differences in fibril morphology. These findings provide insights into the propagation of prions.

MOLECULAR CELL (2021)

Article Microbiology

Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm

Leonardo M. Cortez et al.

Summary: Researchers used a versatile fractionation technique to study the structural heterogeneity of prion strains, revealing that the quaternary structure of prion proteins is a major factor in this heterogeneity. They found that all studied strains underwent significant structural changes resulting in two distinct subpopulations, correlated with strain phenotype. The work provides new insights into the molecular basis of prion strain variation and demonstrates the potential application to other protein misfolding neurodegenerative disorders.

PLOS PATHOGENS (2021)

Article Biochemistry & Molecular Biology

Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity

Jun-Jie Huang et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Cellular models for discovering prion disease therapeutics: Progress and challenges

Saffire H. Krance et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Article Microbiology

Emergence of prions selectively resistant to combination drug therapy

Cassandra M. Burke et al.

PLOS PATHOGENS (2020)

Article Biology

Structural effects of the highly protective V127 polymorphism on human prion protein

Laszlo L. P. Hosszu et al.

COMMUNICATIONS BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

Eric Vallabh Minikel et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

Engineering a murine cell line for the stable propagation of hamster prions

Matthew E. C. Bourkas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Gene-edited murine cell lines for propagation of chronic wasting disease prions

Rupali Walia et al.

SCIENTIFIC REPORTS (2019)

Article Immunology

Variable Protease-Sensitive Prionopathy Transmission to Bank Voles

Romolo Nonno et al.

EMERGING INFECTIOUS DISEASES (2019)

Review Genetics & Heredity

Prions, prionoids and protein misfolding disorders

Claudia Scheckel et al.

NATURE REVIEWS GENETICS (2018)

Article Biochemistry & Molecular Biology

Asparagine and glutamine ladders promote cross-species prion conversion

Timothy D. Kurt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

A naturally occurring variant of the human prion protein completely prevents prion disease

Emmanuel A. Asante et al.

NATURE (2015)

Article Pharmacology & Pharmacy

Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains

Kurt Giles et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Review Biochemistry & Molecular Biology

Mouse Models for Studying the Formation and Propagation of Prions

Joel C. Watts et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

The many shades of prion strain adaptation

Ilia V. Baskakov

Article Multidisciplinary Sciences

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

Jifeng Bian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Microbiology

Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

Joel C. Watts et al.

PLOS PATHOGENS (2014)

Article Multidisciplinary Sciences

Drug resistance confounding prion therapeutics

David B. Berry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein

Joel C. Watts et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell Biology

Prions

David W. Colby et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Virology

Discovery of 2-Aminothiazoles as Potent Antiprion Compounds

Sina Ghaemmaghami et al.

JOURNAL OF VIROLOGY (2010)

Article Virology

Cell-Based Quantification of Chronic Wasting Disease Prions

Jifeng Bian et al.

JOURNAL OF VIROLOGY (2010)

Article Medicine, General & Internal

A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure

Simon Mead et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Biotechnology & Applied Microbiology

A cell line infectible by prion strains from different species

M. -P. Courageot et al.

JOURNAL OF GENERAL VIROLOGY (2008)

Article Multidisciplinary Sciences

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

Magdalini Polymenidou et al.

PLOS ONE (2008)

Article Multidisciplinary Sciences

Prion strain discrimination in cell culture: The cell panel assay

Sukhvir P. Mahal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Multidisciplinary Sciences

A general model of prion strains and their pathogenicity

John Collinge et al.

SCIENCE (2007)

Review Microbiology

The expanding universe of prion diseases

Joel C. Watts et al.

PLOS PATHOGENS (2006)

Article Multidisciplinary Sciences

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

C Korth et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Strain-specified relative conformational stability of the scrapie prion protein

D Peretz et al.

PROTEIN SCIENCE (2001)

Article Multidisciplinary Sciences

Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

D Vilette et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)