Simulating the impact of photoreceptor loss and inner retinal network changes on electrical activity of the retina

Review Engineering, Biomedical

Bioengineering strategies for restoring vision

Jasmina Cehajic-Kapetanovic et al.

Summary: This article discusses the most promising gene therapies, cell therapies, and retinal prostheses for the treatment of retinal degeneration, as well as upcoming technologies for enhancing vision restoration.

NATURE BIOMEDICAL ENGINEERING (2023)

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Article Engineering, Biomedical

An in-silico analysis of electrically evoked responses of midget and parasol retinal ganglion cells in different retinal regions

Xiaoyu Song et al.

Summary: A computational model was developed to assess neural activity in different eccentricities within the human retina. Simulations showed that midget and parasol retinal ganglion cells (RGCs) have region-specific excitation differences under preferred electrode sizes. Smaller electrodes exhibit a higher range of controllable stimulation parameters. Fine-tuning the stimulation amplitude and electrode size can control retinal outputs.

JOURNAL OF NEURAL ENGINEERING (2022)

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Article Engineering, Biomedical

Improving the spatial resolution of artificial vision using midget retinal ganglion cell populations modeled at the human fovea

Michael L. Italiano et al.

Summary: This study developed an anatomically accurate 3D model of RGC populations within the human central retina and demonstrated the potential for an epiretinal hexapolar configuration to achieve consistent, spatially confined retinal responses even within the unique and neuron-dense foveal region.

JOURNAL OF NEURAL ENGINEERING (2022)

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Article Neurosciences

Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation

Jungryul Ahn et al.

Summary: Retinal degeneration results in abnormal rewiring of retinal ganglion cells, leading to a more strongly coupled retinal network. This widespread distribution of electrically evoked RGC spikes may explain the reduced visual acuity in patients implanted with retinal prostheses.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Neurosciences

Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the rd10 Mouse Model

Seongkwang Cha et al.

Summary: Understanding the physiological features of retinal ganglion cells (RGCs) in different stages of retinal degeneration (RD) is crucial for the successful development of retinal prostheses. This study used rd10 mice to investigate RGC responses to light stimulation and electrical stimulation across various postnatal ages. The results showed a decrease in RGC response with degeneration and a difference in the pattern of response between ON and OFF RGCs. The findings suggest the importance of stage-dependent stimulation strategies for retinal prosthesis development.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Multidisciplinary Sciences

Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model

Seongkwang Cha et al.

Summary: By studying electrically evoked retinal responses in a pig RD model, it was found that degenerative retinas required higher charge than normal retinas to generate similar responses. In cases of severe degeneration, it may be challenging to restore patient vision through electrical stimulation.

SCIENTIFIC REPORTS (2021)

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Article Ophthalmology

Advances in Neuroscience, Not Devices, Will Determine the Effectiveness of Visual Prostheses

Bardia Abbasi et al.

Summary: The text reviews the technological and biological obstacles of implementing visual prosthetic devices, highlighting the significant technical challenges and gaps in neuroscience. It emphasizes that further optimization of prosthetic devices alone will not achieve markedly improved visual outcomes without significant advances in our understanding of neuroscience.

SEMINARS IN OPHTHALMOLOGY (2021)

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Article Ophthalmology

Composition of the Inner Nuclear Layer in Human Retina

Rania A. Masri et al.

Summary: This study measured the composition of the inner nuclear layer (INL) in human retina and found that while the absolute density of cell populations varies across the retina, their proportions remain relatively constant. Cone bipolar cells dominate the central retina, with a decrease in proportion towards the periphery balanced by an increase in rod bipolar cells. Despite regional differences in cell density, the neuronal makeup of the INL remains consistent.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

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Review Clinical Neurology

An update on retinal prostheses

Lauren N. Ayton et al.

CLINICAL NEUROPHYSIOLOGY (2020)

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Article Computer Science, Artificial Intelligence

A Three-Dimensional Microelectrode Array to Generate Virtual Electrodes for Epiretinal Prosthesis Based on a Modeling Study

Qing Lyu et al.

INTERNATIONAL JOURNAL OF NEURAL SYSTEMS (2020)

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Review Ophthalmology

Cell types and cell circuits in human and non-human primate retina

Ulrike Gruenert et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2020)

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Article Engineering, Biomedical

Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation

Young Jun Yoon et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2020)

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Article Engineering, Biomedical

Creation of virtual channels in the retina using synchronous and asynchronous stimulation-a modelling study

Xiaoyu Song et al.

JOURNAL OF NEURAL ENGINEERING (2020)

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Article Neurosciences

Mediating Retinal Ganglion Cell Spike Rates Using High-Frequency Electrical Stimulation

Tanruo Guo et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

Response Latency Tuning by Retinal Circuits Modulates Signal Efficiency

Adam Jonatan Tengolics et al.

SCIENTIFIC REPORTS (2019)

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Article Ophthalmology

Topography of Neurons in the Rod Pathway of Human Retina

Sammy C. S. Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

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Article Engineering, Biomedical

Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model

Kyle Loizos et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2018)

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Article Engineering, Biomedical

Differential electrical responses in retinal ganglion cell subtypes: effects of synaptic blockade and stimulating electrode location

Chih Yu Yang et al.

JOURNAL OF NEURAL ENGINEERING (2018)

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Review Ophthalmology

Microperimetry in age: related macular degeneration

E. Midena et al.

EYE (2017)

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Article Engineering, Biomedical

Optimal voltage stimulation parameters for network-mediated responses in wild type and rd10 mouse retinal ganglion cells

Archana Jalligampala et al.

JOURNAL OF NEURAL ENGINEERING (2017)

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Article Multidisciplinary Sciences

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Xiangxi Wang et al.

NATURE COMMUNICATIONS (2017)

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Article Anatomy & Morphology

Classification of Mouse Retinal Bipolar Cells: Type-Specific Connectivity with Special Reference to Rod-Driven AII Amacrine Pathways

Yoshihiko Tsukamoto et al.

FRONTIERS IN NEUROANATOMY (2017)

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Article Multidisciplinary Sciences

High-amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis

Alejandro Barriga-Rivera et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons

David Tsai et al.

SCIENTIFIC REPORTS (2017)

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Review Ophthalmology

Retinal remodeling in human retinitis pigmentosa

B. W. Jones et al.

EXPERIMENTAL EYE RESEARCH (2016)

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Article Engineering, Biomedical

Changes in ganglion cell physiology during retinal degeneration influence excitability by prosthetic electrodes

Alice Cho et al.

JOURNAL OF NEURAL ENGINEERING (2016)

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Article Engineering, Biomedical

Electrical activity of ON and OFF retinal ganglion cells: a modelling study

Tianruo Guo et al.

JOURNAL OF NEURAL ENGINEERING (2016)

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Article Engineering, Biomedical

On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption

Kyle Loizos et al.

PHYSICS IN MEDICINE AND BIOLOGY (2016)

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Article Biology

Connectivity map of bipolar cells and photo receptors in the mouse retina

Christian Behrens et al.

ELIFE (2016)

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Article Engineering, Biomedical

Effects of different three-dimensional electrodes on epiretinal electrical stimulation by modeling analysis

Xun Cao et al.

JOURNAL OF NEUROENGINEERING AND REHABILITATION (2015)

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Review Neurosciences

Origins of spontaneous activity in the degenerating retina

Stuart Trenholm et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

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Article Biochemical Research Methods

Spike-Triggered Covariance Analysis Reveals Phenomenological Diversity of Contrast Adaptation in the Retina

Jian K. Liu et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

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Article Engineering, Biomedical

Quasi-monopolar electrical stimulation of the retina: a computational modelling study

Miganoosh Abramian et al.

JOURNAL OF NEURAL ENGINEERING (2014)

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Article Neurosciences

Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina

Hannah Choi et al.

JOURNAL OF NEUROPHYSIOLOGY (2014)

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Article Neurosciences

INFLUENCE OF THE SODIUM CHANNEL BAND ON RETINAL GANGLION CELL EXCITATION DURING ELECTRIC STIMULATION - A MODELING STUDY

P. Werginz et al.

NEUROSCIENCE (2014)

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Article Multidisciplinary Sciences

Network Oscillations Drive Correlated Spiking of ON and OFF Ganglion Cells in the rd1 Mouse Model of Retinal Degeneration

David J. Margolis et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Pharmacological Analysis of Intrinsic Neuronal Oscillations in rd10 Retina

Sonia Biswas et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Rhythmic Ganglion Cell Activity in Bleached and Blind Adult Mouse Retinas

Jacob Menzler et al.

PLOS ONE (2014)

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Article Neurosciences

The All amacrine cell connectome: a dense network hub

Robert E. Marc et al.

FRONTIERS IN NEURAL CIRCUITS (2014)

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Article Neurosciences

Early remodeling of muller cells in the rd/rd mouse model of retinal dystrophy

Jacqueline Chua et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2013)

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Article Ophthalmology

The Argus™ II retinal prosthesis: Factors affecting patient selection for implantation

Ashish Kishore Ahuja et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2013)

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Article Ophthalmology

Functional Outcome in Subretinal Electronic Implants Depends on Foveal Eccentricity

Katarina Stingl et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

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Article Neurosciences

Upper threshold of extracellular neural stimulation

David Boinagrov et al.

JOURNAL OF NEUROPHYSIOLOGY (2012)

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Article Neurosciences

Dark-adapted response threshold of OFF ganglion cells is not set by OFF bipolar cells in the mouse retina

A. Cyrus Arman et al.

JOURNAL OF NEUROPHYSIOLOGY (2012)

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Article Neurosciences

Intrinsic oscillatory activity arising within the electrically coupled AII amacrine-ON cone bipolar cell network is driven by voltage-gated Na plus channels

Stuart Trenholm et al.

JOURNAL OF PHYSIOLOGY-LONDON (2012)

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Review Neurosciences

The Neuronal Organization of the Retina

Richard H. Masland

NEURON (2012)

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Article Multidisciplinary Sciences

Responses of Retinal Ganglion Cells to Extracellular Electrical Stimulation, from Single Cell to Population: Model-Based Analysis

David Tsai et al.

PLOS ONE (2012)

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Article Cell Biology

The Mechanisms of Repetitive Spike Generation in an Axonless Retinal Interneuron

Mark S. Cembrowski et al.

CELL REPORTS (2012)

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Article Engineering, Biomedical

A continuum model of retinal electrical stimulation

Saiful A. Joarder et al.

JOURNAL OF NEURAL ENGINEERING (2011)

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Article Engineering, Biomedical

Activation of retinal ganglion cells following epiretinal electrical stimulation with hexagonally arranged bipolar electrodes

Miganoosh Abramian et al.

JOURNAL OF NEURAL ENGINEERING (2011)

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Article Neurosciences

Network Oscillations in Rod-Degenerated Mouse Retinas

Jacob Menzler et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Neurosciences

An Intrinsic Neural Oscillator in the Degenerating Mouse Retina

Joanna Borowska et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Pharmacology & Pharmacy

Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice

Yong Sook Goo et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2011)

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Article Neurosciences

Progression of Neuronal and Synaptic Remodeling in the rd10 Mouse Model of Retinitis Pigmentosa

M. Joseph Phillips et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2010)

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Article Ophthalmology

Synaptic Organization of the Vertebrate Retina: General Principles and Species-Specific Variations The Friedenwald Lecture

Samuel M. Wu

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

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Article Mathematical & Computational Biology

Virtual Retina: A biological retina model and simulator, with contrast gain control

Adrien Wohrer et al.

JOURNAL OF COMPUTATIONAL NEUROSCIENCE (2009)

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Article Neurosciences

Receptive Fields of Retinal Bipolar Cells Are Mediated by Heterogeneous Synaptic Circuitry

Ai-Jun Zhang et al.

JOURNAL OF NEUROSCIENCE (2009)

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Review Neurosciences

Receptive fields and functional architecture in the retina

Vijay Balasubramanian et al.

JOURNAL OF PHYSIOLOGY-LONDON (2009)

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Review Neurosciences

The diverse functional roles and regulation of neuronal gap junctions in the retina

Stewart A. Bloomfield et al.

NATURE REVIEWS NEUROSCIENCE (2009)

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Article Multidisciplinary Sciences

A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the Dynamic Range of the Retina

Rodrigo Publio et al.

PLOS ONE (2009)

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Article Neurosciences

Receptive field properties of ON- and OFF-ganglion cells in the mouse retina

Michiel Van Wyk et al.

VISUAL NEUROSCIENCE (2009)

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Article Neurosciences

Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse

Steven F. Stasheff

JOURNAL OF NEUROPHYSIOLOGY (2008)

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Article Neurosciences

Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input

David J. Margolis et al.

JOURNAL OF NEUROSCIENCE (2008)

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Article Ophthalmology

Neural reprogramming in retinal degeneration

Robert E. Marc et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)

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Article Computer Science, Artificial Intelligence

A realistic model of rod photoreceptor for use in a retina network model

Rodrigo Publio et al.

NEUROCOMPUTING (2006)

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Article Neurosciences

The photocurrent response of human cones is fast and monophasic

J. H. van Hateren et al.

BMC NEUROSCIENCE (2006)

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Article Engineering, Biomedical

Sites of neuronal excitation by epiretinal electrical stimulation

MA Schiefer et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2006)

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Review Ophthalmology

Retinal remodeling during retinal degeneration

BW Jones et al.

EXPERIMENTAL EYE RESEARCH (2005)

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Article Engineering, Biomedical

A bidomain model of epiretinal stimulation

S Dokos et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2005)

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Article Neurosciences

Physiological properties of rod photoreceptor electrical coupling in the tiger salamander retina

J Zhang et al.

JOURNAL OF PHYSIOLOGY-LONDON (2005)

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Article Engineering, Biomedical

How the retinal network reacts to epiretinal stimulation to form the prosthetic visual input to the cortex

Nicolas P. Cottaris et al.

JOURNAL OF NEURAL ENGINEERING (2005)

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Article Neurosciences

Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide

DE Kourennyi et al.

JOURNAL OF NEUROPHYSIOLOGY (2004)

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Article Computer Science, Interdisciplinary Applications

A model for the electrically stimulated retina

S Resatz et al.

MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS (2004)

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Article Neurosciences

Simulation of artificial vision: I. Eccentric reading of isolated words, and perceptual learning

J Sommerhalder et al.

VISION RESEARCH (2003)

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Article Medicine, Research & Experimental

Mechanisms of electrical stimulation with neural prostheses

F Rattay et al.

NEUROMODULATION (2003)

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Simulating the impact of photoreceptor loss and inner retinal network changes on electrical activity of the retina

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