期刊
JOURNAL OF NATURAL PRODUCTS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00669
关键词
-
资金
- Shandong Provincial Natural Science Foundation
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- NSFC-Shandong Joint Fund
- [ZR2021MH257]
- [41976105]
- [201941001]
- [U1906212]
Sixteen new biisoflavones were discovered from the culture of Streptomyces sp. HDN154127, derived from the Takla Makan desert. The structures of the compounds were determined using NMR, MS, and ECD analyses, and they exhibited significant antibacterial activity.
Sixteen new biisoflavones, bisoflavolins A-N (1-16), were discovered from cultures of the Takla Makan desert-derived strain Streptomyces sp. HDN154127. The chemical structures, including axial chirality, were elucidated by NMR, MS, and ECD analyses. Antibacterial activity of dimerized compounds was tested against seven different bacteria. The dimerized compounds showed better activity (MIC from 0.8 to 50.0 mu M) than the corresponding monomers (daidzein and genistein, MIC > 50.0 mu M). The rare dimeric and chlorinated structures in 1-16 were proved to be biotransformation products obtained from soy isoflavones and sodium chloride, which constituted the culture medium. This is the first report of an actinomycete that promotes both dimerization and chlorination utilizing natural isoflavones as skeletons sources.
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