A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins (2-6) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F (3) was the most active with an IC50 value of 0.39 mu M against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that 3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.

Automated summary

A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from Physalis minima whole plant collected in Thailand. Among them, physalin F (3) showed the strongest activity against TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.