相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。How the structural properties of the indole derivatives are important in kinase targeted drug design?: A case study on tyrosine kinase inhibitors
Dipayan Mondal et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2022)
RCSB Protein Data Bank: Celebrating 50 years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D
Stephen K. Burley et al.
PROTEIN SCIENCE (2022)
HDAC6 as privileged target in drug discovery: A perspective
Sravani Pulya et al.
PHARMACOLOGICAL RESEARCH (2021)
Histone deacetylase 2 selective inhibitors: A versatile therapeutic strategy as next generation drug target in cancer therapy
Manasa Gangadhar Shetty et al.
PHARMACOLOGICAL RESEARCH (2021)
Quantitative activity-activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies
Sk Abdul Amin et al.
NEW JOURNAL OF CHEMISTRY (2021)
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
Michael Morgen et al.
CHEMMEDCHEM (2020)
HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia
Marco Spreafico et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors
Qiuqiong Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated
Magalie Geraldy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Indole: A privileged scaffold for the design of anti-cancer agents
Yichao Wan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Molecular characterization of HDAC8 deletions in individuals with atypical Cornelia de Lange syndrome
Maria Helgeson et al.
JOURNAL OF HUMAN GENETICS (2018)
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6
G. R. Vanaja et al.
CELL COMMUNICATION AND SIGNALING (2018)
Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors
Chunlong Zhao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms
Sakineh Dadashpour et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities
Shi-Wei Chao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status
Xiaoyang Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4
Diana Lamaa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
Martin Marek et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Design, synthesis, and preliminary bioactivity evaluation of N1-hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors
Xue Wang et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2017)
Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study
Xiaoyang Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery
S. K. Abdul Amin et al.
FUTURE MEDICINAL CHEMISTRY (2017)
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
Tino Heimburg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
First report on the structural exploration and prediction of new BPTES analogs as glutaminase inhibitors
Sk. Abdul Amin et al.
JOURNAL OF MOLECULAR STRUCTURE (2017)
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells
Jiun-I Lai et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase
Idris Raji et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity
Raffaella Cincinelli et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases
Alokta Chakrabarti et al.
FUTURE MEDICINAL CHEMISTRY (2016)
Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket
Alexa A. Tabackman et al.
JOURNAL OF STRUCTURAL BIOLOGY (2016)
Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8
Christophe Decroos et al.
BIOCHEMISTRY (2015)
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity
Xiaoyang Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation
I. Rettig et al.
CELL DEATH & DISEASE (2015)
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors
Yiwu Yao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells
Hsueh-Yun Lee et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni
Diana A. Stolfa et al.
JOURNAL OF MOLECULAR BIOLOGY (2014)
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Edward Seto et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Exploring structural requirements of leads for improving activity and selectivity against CDK5/p25 in Alzheimer's disease: an in silico approach
Pravin Ambure et al.
RSC ADVANCES (2014)
The Up-Regulation of Histone Deacetylase 8 Promotes Proliferation and Inhibits Apoptosis in Hepatocellular Carcinoma
Jian Wu et al.
DIGESTIVE DISEASES AND SCIENCES (2013)
Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni
Martin Marek et al.
PLOS PATHOGENS (2013)
X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face
Magdalena Harakalova et al.
JOURNAL OF MEDICAL GENETICS (2012)
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold
Melissa M. Kemp et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group
Yingjie Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
PaDEL-Descriptor: An Open Source Software to Calculate Molecular Descriptors and Fingerprints
Chun Wei Yap
JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of ΔF508-CFTR
Darren M. Hutt et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Histone Deacetylase 8 Is Required for Centrosome Cohesion and Influenza A Virus Entry
Yohei Yamauchi et al.
PLOS PATHOGENS (2011)
Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222
Stefania Terracciano et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity
Luciana Auzzas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors
Giuseppe Giannini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
David V. Smil et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
Janine Arts et al.
CLINICAL CANCER RESEARCH (2009)
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo
Philip Jones et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity
Oscar M. Moradei et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex
Alessandro Vannini et al.
EMBO REPORTS (2007)
Functional differences in epigenetic modulators - Superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies
Alan P. Kozikowski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A series of novel, potent, and selective histone deacetylase inhibitors
Philip Jones et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
JR Somoza et al.
STRUCTURE (2004)
Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A
H Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
A Vannini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cloning and characterization of a novel human. Class I histone deacetylase that functions as a transcription repressor
E Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
