Genosensor design and strategies towards electrochemical deoxyribonucleic acid (DNA) signal transduction: Mechanism of interaction

Quantum dots have been used widely for nucleic acid-based sensing as biocompatible and extremely sensitive to environmental perturbations like electrical doping and molecule adsorption. Electrochemical deoxyribonucleic acid (DNA) sensors are easy operating mode systems, making them suitable for pointof-care (POC) testing. This review provides an overview of the electrochemical genosensors established in the previous and current years for nanomaterial (NMs)-DNA interaction. In this short review, we discuss An ion-interacting mechanism between quantum dots and genosensors, including ssDNA and dsDNA sensors based on redox-active layer. Focus on genosensor design and combines the ionic system with nanotechnology to build a functioning interface and electrochemical DNA signal detection. A concluding section identifies the field's current difficulties and potential future directions. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

This review provides an overview of the development of electrochemical genosensors established in the past few years and discusses the ion-interacting mechanism between quantum dots and genosensors. It focuses on genosensor design and the combination of ionic systems and nanotechnology to build a functional interface for electrochemical DNA signal detection.