Bipyridine adducts of Zn(II) and Ni(II) bis ( N-methyl- N-phenyl dithiocarbamate): Synthesis, characterization, and biological applications

Substituted bipyridine adducts of Zn(II) and Ni(II) bis ( N-methyl -N-phenyl dithiocarbamate) have been synthesized by the reaction of the dithiocarbamate complexes with 4, 4 ' bipyridine, 4, 4'-dimethyl-2,2 bipyridine, 4,4'-dimethoxy-2,2'-bipyridine, 4,4'-ditertbutyl-2,2' bipyridine. The resulting adduct were rep-resented as [M(L)2(B)], [M(L)2(DMeB)], [M(L)2(DMxB)] and [M(L)2(DTB)] respectively, (where M = Zn/Ni), and characterized using elemental analysis, various spectroscopic techniques and X-ray single crystal-lography. The spectroscopic data suggest octahedral coordination around the metal center due to the formation of a new M-N bond with the nitrogen of the Lewis bases. A considerable shift occurred in the peaks found in the vicinity of the M-N coordination upon the formation of the adducts. Single crystal data obatined for [Zn(L)2(B)] and [Zn(L)2(DMeB)] revealed a five and six geometry respectively around the Zn center in the adducts. Furthermore, the compounds were evaluated for cytotoxicity, an-tioxidant, and anti-inflammatory properties. Although all the biological studies conducted generally re-vealed a concentration-dependent profile, no noticeable trends were found even with the compounds that exhibited structural similarities. Nevertheless, the compounds showed good activity, with IC50 rang-ing from 0.0 0 03 to 17.38 mu g/mL, which was better than the standard 5-Fluorouracil (5 FU) used in the cytotoxicity study. The adducts had a better antioxidant property in DPPH assay than in all the used an-tioxidant assays. Upon evaluation in a Bovine serum albumin denaturation assay, they also possessed a better anti-inflammatory property than diclofenac.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

In this study, substituted bipyridine adducts of Zn(II) and Ni(II) bis(N-methyl-N-phenyl dithiocarbamate) were synthesized and characterized. The adducts exhibited octahedral coordination around the metal center and showed activities in cytotoxicity, antioxidant, and anti-inflammatory assays. These compounds had stronger activity compared to the standard drug 5-Fluorouracil.