Isatin derived novel Schiff bases: An efficient pharmacophore for versatile biological applications

Novel Schiff bases were synthesized, from isatin and selected amines and characterized by UV, IR, MS, H-1, and C-13 NMR spectroscopic techniques. The isatin analogues were evaluated for different pharmacological activities like including antioxidant activity, antimicrobial, and enzyme inhibition. Antioxidant capacity was evaluated by molecular docking studies with an antioxidant enzyme (PDB ID: 1HD2) and experimentally by DPPH method. Furthermore, the in vitro cytotoxicity studies were conducted against HepG2, H9c2 cell lines by MIT assay and DLA cell lines by Trypan blue exclusion method. An evaluation method called the ADMET scoring function for the evaluation of drug-likeness properties and the boiled egg model was also introduced to check the Blood-Brain Barrier (BBB) permeability and gastrointestinal (GI) absorption. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

Novel Schiff bases were synthesized and characterized. They were evaluated for various pharmacological activities and their drug-likeness properties were assessed. In addition, their cytotoxicity and blood-brain barrier permeability were investigated.