☆ 4.4 Article

A Cocktail of Polyherbal Bioactive Compounds and Regular Mobility Training as Senolytic Approaches in Age-dependent Alzheimer's: the In Silico Analysis, Lifestyle Intervention in Old Age

JOURNAL OF MOLECULAR NEUROSCIENCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell Biology

Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases

Navid Abedpoor et al.

Summary: Adipose tissue is a dynamic organ in the endocrine system that regulates metabolism, inflammation, energy homeostasis, and thermogenesis. Physical activity plays a crucial role in maintaining adipose tissue function and preventing metabolic disorders.

ACTA HISTOCHEMICA (2022)

添加到收藏夹

Article Neurosciences

Cross Brain-Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Navid Abedpoor et al.

Summary: Depression is a mood disorder that can impair the brain-gut axis. This study found that lncRNAs profile and Kdr/Vegf alpha/Pten/Bdnf interactions network in the hippocampus and ileum could be important in the brain-gut axis. KDR was identified as a potential target for treating major depressive disorder. Exercise and leucine were found to improve the brain-gut axis in mice with depression-like behaviors. The findings suggest that lncRNAs profiles could serve as biomarkers for diagnosis and prognosis, and exercise + leucine could be a practical approach to improve depression.

MOLECULAR NEUROBIOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

The Use of Artificial Intelligence in Complementary and Alternative Medicine: A Systematic Scoping Review

Hongmin Chu et al.

Summary: The development of artificial intelligence in complementary and alternative medicine has been rapidly advancing. This systematic scoping review identified three main categories of AI usage in CAM, including acupuncture treatment, tongue and lip diagnoses, and herbal medicine. Future research should focus on verifying and validating these AI models through large-scale clinical trials.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

MNDR v3.0: mammal ncRNA-disease repository with increased coverage and annotation

Lin Ning et al.

Summary: The update to version 3.0 of the mammal ncRNA-disease repository (MNDR) has significantly increased the amount of data and expanded the categories of ncRNAs and mammalian species. This update also includes additional information on drug annotations, subcellular localizations, and interactions of ncRNAs, as well as providing prediction tools for miRNA/lncRNA/circRNA-disease associations. The optimized website now offers a more practical and user-friendly interface, making MNDR v3.0 a valuable resource for research into disease mechanisms and clinical treatment strategies.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Zingiber officinale ameliorates Alzheimer's disease and Cognitive Impairments: Lessons from preclinical studies

Marjan Talebi et al.

Summary: Alzheimer's disease is a neurodegenerative condition mainly found in elderly individuals, with symptoms including cognitive impairments. Research suggests that ginger and its components have the potential to improve and alleviate cognitive dysfunctions, but further studies are needed to evaluate their pharmacological and pharmaceutical aspects.

BIOMEDICINE & PHARMACOTHERAPY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

Stephen K. Burley et al.

Summary: RCSB PDB, as the US data center for the global PDB archive, provides free access to 3D macromolecular structure data for millions of users worldwide, including educators, students, and the general public, integrating over 40 external biodata resources. The redesigned website now features improved search functionality and easier access to PDB data, showcasing new structures relevant to the understanding and addressing of the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

Pouria Mosaddeghi et al.

Summary: The study found that several plants used in TPM have active ingredients that regulate autophagy or its upstream pathways, indicating a potential role in antiaging mechanisms involving autophagy. Gene set enrichment analysis and reconstruction of protein-protein interaction networks suggested mTOR as a key network hub. Furthermore, chemoinformatics study identified cyclo-trijuglone of Juglans regia L. as a potential ATP-competitive inhibitor of mTOR among other compounds.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Shweta Devi et al.

Summary: Neurodegenerative disorders such as PD, AD, ALS, and HD are of great concern due to the lack of effective therapy and increasing number of cases. Small molecules like flavonoids have potential in reducing cellular stress and have gained attention for their antioxidant, anti-inflammatory, and anti-apoptotic properties. Further research is needed to uncover the mechanisms behind the protective effects of flavonoids against cellular stress response in neurodegenerative disorders.

BIOMEDICINES (2021)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Nutrition and the Hallmarks of Aging

Virecoulon K. Giudici

JOURNAL OF NUTRITION HEALTH & AGING (2021)

添加到收藏夹

Review Nutrition & Dietetics

Mediterranean diet and the hallmarks of ageing

Oliver M. Shannon et al.

Summary: Ageing is a multifactorial process that involves reduced function and increased risk of diseases and death. Healthy dietary patterns can reduce the risk of age-related diseases and increase longevity by positively influencing cellular and molecular hallmarks of ageing. The Mediterranean dietary pattern, characterized by plant-based foods, has been associated with better health during ageing and may impact each hallmark of ageing positively.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

添加到收藏夹

Article History & Philosophy Of Science

Aging biomarkers and the measurement of health and risk

Sara Green et al.

Summary: This paper discusses the increasing focus on preventing age-related disorders, exploring new opportunities to slow down the aging process through interventions such as personalized nutrition. The development of a new aging biomarker is proposed, with a combination of philosophical analysis and ethnographic fieldwork to examine the management of aging and the societal and ethical implications of reframing aging as a risk.

HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES (2021)

添加到收藏夹

Article Medicine, General & Internal

Alzheimer disease

David S. Knopman et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive impairments. The pathophysiology involves a complex interplay of loss of synaptic homeostasis and dysfunction in endosomal/lysosomal clearance pathways. Therapeutic options are still being sought to substantially alter the clinical course of individuals with Alzheimer's disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mediterranean diet and cognitive function: From methodology to mechanisms of action

Mario Siervo et al.

Summary: The traditional Mediterranean diet is recognized for its protective effects against cardiovascular diseases, diabetes, and maintaining cognitive health. While clinical trial results are inconsistent, observational studies suggest that the diet may be effective for early prevention of dementia.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Healthy Aging-Relevant Goals: The Role of Person-Context Co-construction

Hans-Werner Wahl et al.

Summary: This article discusses how individuals' motivation for healthy aging is influenced by different contexts as they age. The concept of co-construction is used to argue that both individuals and contexts contribute to the formation, maintenance, and disengagement from health goals in adulthood and old age. The study proposes four conceptual refinements to healthy aging models, emphasizing the impact of context on individuals' health goals and how these impacts change as individuals move through different aging stages.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis

Dechao Bu et al.

Summary: Gene set enrichment analysis is crucial for extracting biological insights from genome-scale experiments. The latest version of KOBAS, KOBAS-i, introduces a machine learning-based method CGPS, expands exploratory visualization of enriched results, and increases the number of supported species.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Nutrition & Dietetics

Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet

Fatemeh Azizian-Farsani et al.

Summary: The study demonstrated that the herbal extract (HE) can prevent colitis induced by high AGEs-fat diet in obese mice. HE reduced inflammation, apoptosis, maintained immune homeostasis, and improved colitis in obese mice by modulating multiple signaling pathways.

NUTRITION & METABOLISM (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Predicting Drug-Induced Liver Injury Using Machine Learning on a Diverse Set of Predictors

Temidayo Adeluwa et al.

Summary: The goal of the CAMDA 2020 CMap Drug Safety Challenge was to develop prediction models for drug-induced liver injury (DILI) using multiple data sources. Models based solely on gene expression showed varying results, prompting the need to combine various data types for improved accuracy in predicting clinical DILI subtypes. Traditional machine learning approaches may not be the most optimal classification method for the current data.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Hospitality, Leisure, Sport & Tourism

Impacts of exercise interventions on different diseases and organ functions in mice

Shanshan Guo et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Mechanisms of aging and potential role of selected polyphenols in extending healthspan

Gian Luigi Russo et al.

BIOCHEMICAL PHARMACOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database

Hsi-Yuan Huang et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Neuroprotective Effects of Quercetin in Alzheimer's Disease

Haroon Khan et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer's Disease in Euthyroid Subjects

Byung Wook Choi et al.

THYROID (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

Le Chang et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Zhenyu Bao et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Medicine, General & Internal

Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis

Mika Kivimaki et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer's Disease and Parkinson's Disease

Akira Nakajima et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

LncBook: a curated knowledgebase of human long non-coding RNAs

Lina Ma et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Multidisciplinary Sciences

The biochemical basis of microRNA targeting efficacy

Sean E. McGeary et al.

SCIENCE (2019)

添加到收藏夹

Article Integrative & Complementary Medicine

Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

Chang-Yul Kim et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

添加到收藏夹

Article Immunology

Imbalance of Circulating T(h)17 and Regulatory T Cells in Alzheimer's Disease: A Case Control Study

Timo Jan Oberstein et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

miRWalk: An online resource for prediction of microRNA binding sites

Carsten Sticht et al.

PLOS ONE (2018)

添加到收藏夹

Review Geriatrics & Gerontology

Botanical Sources for Alzheimer's: A Review on Reports From Traditional Persian Medicine

Ayda Hosseinkhani et al.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

Michael K. Gilson et al.

NUCLEIC ACIDS RESEARCH (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

PubChem Substance and Compound databases

Sunghwan Kim et al.

NUCLEIC ACIDS RESEARCH (2016)

添加到收藏夹

Article Cell Biology

High dietary advanced glycation end products are associated with poorer spatial learning and accelerated A deposition in an Alzheimer mouse model

Irit Lubitz et al.

AGING CELL (2016)

添加到收藏夹

Article Oncology

Use of complementary and alternative medicine and breast cancer survival in the Health, Eating, Activity, and Lifestyle Study

Marian L. Neuhouser et al.

BREAST CANCER RESEARCH AND TREATMENT (2016)

添加到收藏夹

Editorial Material Medicine, General & Internal

Adapting to Artificial Intelligence Radiologists and Pathologists as Information Specialists

Saurabh Jha et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

添加到收藏夹

Review Geriatrics & Gerontology

Long noncoding RNAs and Alzheimer's disease

Qiong Luo et al.

CLINICAL INTERVENTIONS IN AGING (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer's Disease

Dong-Mei Wang et al.

NEUROCHEMICAL RESEARCH (2014)

添加到收藏夹

Review Neurosciences

Therapeutics of Alzheimer's disease: Past, present and future

R. Anand et al.

NEUROPHARMACOLOGY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

添加到收藏夹

Article Plant Sciences

Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells

Jinyoung Hur et al.

PHARMACEUTICAL BIOLOGY (2013)

添加到收藏夹

Article Behavioral Sciences

Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish

S. K. Richetti et al.

BEHAVIOURAL BRAIN RESEARCH (2011)

添加到收藏夹

Article Pharmacology & Pharmacy

Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation

Yanji Cui et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)

添加到收藏夹

Article Geriatrics & Gerontology

Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway

Mi Kyung Kim et al.

EXPERIMENTAL GERONTOLOGY (2010)

添加到收藏夹

Article Geriatrics & Gerontology

Complex Mental and Physical Activity in Older Women and Cognitive Performance: A 6-month Randomized Controlled Trial

Verena Klusmann et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)

添加到收藏夹

Review Medicine, General & Internal

Mechanisms of Disease: Interleukin-17 and Type 17 Helper T Cells.

Pierre Miossec et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Neurosciences

Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic

F. Misiti et al.

BRAIN RESEARCH BULLETIN (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Pamela Maher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

添加到收藏夹

Review Plant Sciences

Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles

S Chrubasik et al.

PHYTOMEDICINE (2005)

添加到收藏夹

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.