Sustained release properties of liquid crystal functionalized poly (amino acid)s nanoparticles

Drug-loaded nanoparticles can lower the adverse effects of antitumor drugs and have good biosafety. Herein, a series of amphiphilic poly (amino acid)s materials were designed to prepare drug-loaded nanoparticles by physical encapsulation and chemical bonding. The introduction of cholesterol makes the material show the properties of liquid crystal, and facilitates the regular arrangement of macro-molecules so that it can be well self-assembled. The morphologies with different shapes in different envi-ronments such as spheres or rod were observed. CCK-8 experiment proved the synthesized material was low-toxic to normal cells, and had significant targeting and proliferation inhibition of cancer cells. Nanoparticles entered cells slowly through endocytosis and interact with lysosomes to release drugs. Drug release in vitro shows that the nanoparticles have temperature/pH dual responsiveness.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Amphiphilic poly (amino acid)s materials were designed to prepare drug-loaded nanoparticles, which can reduce the adverse effects of antitumor drugs and have good biosafety. The introduction of cholesterol makes the material exhibit liquid crystal properties, facilitating the self-assembly of macro-molecules. Different morphologies, such as spheres or rods, were observed in different environments. The synthesized material showed low toxicity to normal cells and significant targeting and proliferation inhibition of cancer cells. The nanoparticles entered cells slowly through endocytosis and interacted with lysosomes to release drugs. In vitro drug release experiments demonstrated temperature/pH dual responsiveness of the nanoparticles.