ISPRED-SEQ: Deep Neural Networks and Embeddings for Predicting Interaction Sites in Protein Sequences

The knowledge of protein-protein interaction sites (PPIs) is crucial for protein functional annotation. Here we address the problem focusing on the prediction of putative PPIs considering as input protein sequences. The issue is important given the huge volume of protein sequences compared to experimental and/or computed structures. Taking advantage of protein language models, recently developed, and Deep Neural networks, here we describe ISPRED-SEQ, which overpasses state-of-the-art predictors addressing the same problem. ISPRED-SEQ is freely available for testing at https://ispredws.biocomp.unibo.it. & COPY; 2023 The Author(s). Published by Elsevier Ltd.

Automated summary

This article introduces a method called ISPRED-SEQ for predicting protein-protein interaction sites based on protein sequences. It utilizes recently developed protein language models and deep neural networks, outperforming other similar methods.