相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Escaping from Flatland: Stereoconvergent Synthesis of Three-Dimensional Scaffolds via Ruthenium(II)-Catalyzed Noyori-Ikariya Transfer Hydrogenation
Andrej Emanuel Cotman
CHEMISTRY-A EUROPEAN JOURNAL (2021)
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens
Martina Durcik et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks
Andrej Emanuel Cotman et al.
ACS OMEGA (2021)
The global preclinical antibacterial pipeline
Ursula Theuretzbacher et al.
NATURE REVIEWS MICROBIOLOGY (2020)
Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates
Andraz Lamut et al.
BIOORGANIC CHEMISTRY (2020)
Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity
Benedetta Fois et al.
CHEMMEDCHEM (2020)
Antibiotics in the clinical pipeline in October 2019
Mark S. Butler et al.
JOURNAL OF ANTIBIOTICS (2020)
Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery
Martina Durcik et al.
ACS OMEGA (2020)
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV
Yimin Hu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
Ziga Skok et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Rational design of balanced dual-targeting antibiotics with limited resistance
Akos Nyerges et al.
PLOS BIOLOGY (2020)
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors
Davide Benedetto Tiz et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Analysis of the clinical antibacterial and antituberculosis pipeline
Ursula Theuretzbacher et al.
LANCET INFECTIOUS DISEASES (2019)
New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors
Nace Zidar et al.
MEDCHEMCOMM (2019)
Recent progress in the discovery and development of DNA gyrase B inhibitors
Michaela Barancokova et al.
FUTURE MEDICINAL CHEMISTRY (2018)
DIALS: implementation and evaluation of a new integration package
Graeme Winter et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)
Predictive compound accumulation rules yield a broad - spectrum antibiotic
Michelle F. Richter et al.
NATURE (2017)
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E-coli type I signal peptidase (LepB)
Maria De Rosa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors
Marina Gjorgjieva et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure Property Relationships of Carboxylic Acid Isosteres
Pierrik Lassalas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation
Nace Zidar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site
Tihomir Tomasic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
A New-Class Antibacterial-Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
Gregory S. Bisacchi et al.
ACS INFECTIOUS DISEASES (2015)
Mechanism of Quinolone Action and Resistance
Katie J. Aldred et al.
BIOCHEMISTRY (2014)
Prospects for Developing New Antibacterials Targeting Bacterial Type IIA Topoisomerases
Tihomir Tomašić et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
Development of a high-throughput electrophysiological assay for the human ether-a-go-go related potassium channel hERG
Daniel J. Gillie et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2013)
Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay
Mark L. Cunningham et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Improvement of molecular-replacement models with Sculptor
Gabor Bunkoczi et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
Frederic Collin et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)
Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy
Brian A. Sherer et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry
Minoru Ishikawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
xia2: an expert system for macromolecular crystallography data reduction
G. Winter
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)
Functional relationship between bacterial cell density and the efficacy of antibiotics
Klas I. Udekwu et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Frank Lovering et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824
Xiaojin Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The fluorometric microculture cytotoxicity assay
Elin Lindhagen et al.
NATURE PROTOCOLS (2008)
Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility
Xianghong Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
Ian W. Davis et al.
NUCLEIC ACIDS RESEARCH (2007)
Circumventing the crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants
Lisa D. Marroquin et al.
TOXICOLOGICAL SCIENCES (2007)
Synthesis of 2-substituted endo-hymenialdisine derivatives
Qinfei He et al.
TETRAHEDRON LETTERS (2007)
Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics
Peter Ballard et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
The Buccaneer software for automated model building.: 1.: Tracing protein chains
Kevin Cowtan
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2006)
Human Hepatocytes in primary culture:: The choice to investigate drug metabolism in man
MJ Gómez-Lechón et al.
CURRENT DRUG METABOLISM (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]-quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists
DG Brown et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists.: 1.: Heterocyclic substituted 5-alkyl derivatives
MJ Fray et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)